Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”

Circadian variations in the corrected QT (QTc) interval have been documented in clinical trials. Animal models show circadian variations in expression of the cardiac ion channels that are necessary to maintain the heart's electrophysiological properties. Can these diurnal rhythms in QTc affect...

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Detalles Bibliográficos
Autores principales: Garnett, C, Johannesen, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036419/
https://www.ncbi.nlm.nih.gov/pubmed/27647678
http://dx.doi.org/10.1002/psp4.12128
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author Garnett, C
Johannesen, L
author_facet Garnett, C
Johannesen, L
author_sort Garnett, C
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description Circadian variations in the corrected QT (QTc) interval have been documented in clinical trials. Animal models show circadian variations in expression of the cardiac ion channels that are necessary to maintain the heart's electrophysiological properties. Can these diurnal rhythms in QTc affect the ability of a drug to delay cardiac repolarization?
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spelling pubmed-50364192016-09-29 Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration” Garnett, C Johannesen, L CPT Pharmacometrics Syst Pharmacol Commentary Circadian variations in the corrected QT (QTc) interval have been documented in clinical trials. Animal models show circadian variations in expression of the cardiac ion channels that are necessary to maintain the heart's electrophysiological properties. Can these diurnal rhythms in QTc affect the ability of a drug to delay cardiac repolarization? John Wiley and Sons Inc. 2016-09-20 2016-09 /pmc/articles/PMC5036419/ /pubmed/27647678 http://dx.doi.org/10.1002/psp4.12128 Text en © 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentary
Garnett, C
Johannesen, L
Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”
title Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”
title_full Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”
title_fullStr Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”
title_full_unstemmed Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”
title_short Commentary on: “Levofloxacin‐Induced QTc Prolongation Depends on the Time of Drug Administration”
title_sort commentary on: “levofloxacin‐induced qtc prolongation depends on the time of drug administration”
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036419/
https://www.ncbi.nlm.nih.gov/pubmed/27647678
http://dx.doi.org/10.1002/psp4.12128
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