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Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity

BACKGROUND: Previous research has shown that the human brain can be represented as a complex functional network that is characterized by specific topological properties, such as clustering coefficient, characteristic path length, and global/local efficiency. Patients with psychotic disorder may have...

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Autores principales: Peeters, Sanne C. T., Gronenschild, Ed H. B. M., van Amelsvoort, Therese, van Os, Jim, Marcelis, Machteld, Kahn, Rene, Wiersma, Durk, Bruggeman, Richard, Cahn, Wiepke, de Haan, Lieuwe, Meijer, Carin, Myin‐Germeys, Inez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036431/
https://www.ncbi.nlm.nih.gov/pubmed/27688938
http://dx.doi.org/10.1002/brb3.508
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author Peeters, Sanne C. T.
Gronenschild, Ed H. B. M.
van Amelsvoort, Therese
van Os, Jim
Marcelis, Machteld
Kahn, Rene
Wiersma, Durk
Bruggeman, Richard
Cahn, Wiepke
de Haan, Lieuwe
Meijer, Carin
Myin‐Germeys, Inez
author_facet Peeters, Sanne C. T.
Gronenschild, Ed H. B. M.
van Amelsvoort, Therese
van Os, Jim
Marcelis, Machteld
Kahn, Rene
Wiersma, Durk
Bruggeman, Richard
Cahn, Wiepke
de Haan, Lieuwe
Meijer, Carin
Myin‐Germeys, Inez
author_sort Peeters, Sanne C. T.
collection PubMed
description BACKGROUND: Previous research has shown that the human brain can be represented as a complex functional network that is characterized by specific topological properties, such as clustering coefficient, characteristic path length, and global/local efficiency. Patients with psychotic disorder may have alterations in these properties with respect to controls, indicating altered efficiency of network organization. This study examined graph theoretical changes in relation to differential genetic risk for the disorder and aimed to identify clinical correlates. METHODS: Anatomical and resting‐state MRI brain scans were obtained from 73 patients with psychotic disorder, 83 unaffected siblings, and 72 controls. Topological measures (i.e., clustering coefficient, characteristic path length, and small‐worldness) were used as dependent variables in a multilevel random regression analysis to investigate group differences. In addition, associations with (subclinical) psychotic/cognitive symptoms were examined. RESULTS: Patients had a significantly lower clustering coefficient compared to siblings and controls, with no difference between the latter groups. No group differences were observed for characteristic path length and small‐worldness. None of the topological properties were associated with (sub)clinical psychotic and cognitive symptoms. CONCLUSIONS: The reduced ability for specialized processing (reflected by a lower clustering coefficient) within highly interconnected brain regions observed in the patient group may indicate state‐related network alterations. There was no evidence for an intermediate phenotype and no evidence for psychopathology‐related alterations.
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spelling pubmed-50364312016-09-29 Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity Peeters, Sanne C. T. Gronenschild, Ed H. B. M. van Amelsvoort, Therese van Os, Jim Marcelis, Machteld Kahn, Rene Wiersma, Durk Bruggeman, Richard Cahn, Wiepke de Haan, Lieuwe Meijer, Carin Myin‐Germeys, Inez Brain Behav Original Research BACKGROUND: Previous research has shown that the human brain can be represented as a complex functional network that is characterized by specific topological properties, such as clustering coefficient, characteristic path length, and global/local efficiency. Patients with psychotic disorder may have alterations in these properties with respect to controls, indicating altered efficiency of network organization. This study examined graph theoretical changes in relation to differential genetic risk for the disorder and aimed to identify clinical correlates. METHODS: Anatomical and resting‐state MRI brain scans were obtained from 73 patients with psychotic disorder, 83 unaffected siblings, and 72 controls. Topological measures (i.e., clustering coefficient, characteristic path length, and small‐worldness) were used as dependent variables in a multilevel random regression analysis to investigate group differences. In addition, associations with (subclinical) psychotic/cognitive symptoms were examined. RESULTS: Patients had a significantly lower clustering coefficient compared to siblings and controls, with no difference between the latter groups. No group differences were observed for characteristic path length and small‐worldness. None of the topological properties were associated with (sub)clinical psychotic and cognitive symptoms. CONCLUSIONS: The reduced ability for specialized processing (reflected by a lower clustering coefficient) within highly interconnected brain regions observed in the patient group may indicate state‐related network alterations. There was no evidence for an intermediate phenotype and no evidence for psychopathology‐related alterations. John Wiley and Sons Inc. 2016-06-29 /pmc/articles/PMC5036431/ /pubmed/27688938 http://dx.doi.org/10.1002/brb3.508 Text en © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Peeters, Sanne C. T.
Gronenschild, Ed H. B. M.
van Amelsvoort, Therese
van Os, Jim
Marcelis, Machteld
Kahn, Rene
Wiersma, Durk
Bruggeman, Richard
Cahn, Wiepke
de Haan, Lieuwe
Meijer, Carin
Myin‐Germeys, Inez
Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
title Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
title_full Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
title_fullStr Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
title_full_unstemmed Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
title_short Reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
title_sort reduced specialized processing in psychotic disorder: a graph theoretical analysis of cerebral functional connectivity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036431/
https://www.ncbi.nlm.nih.gov/pubmed/27688938
http://dx.doi.org/10.1002/brb3.508
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