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Concept of an upright wearable positron emission tomography imager in humans

BACKGROUND: Positron Emission Tomography (PET) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain‐dedicated imaging. Our team has explored the concept of wearable PET imagers which could provide functional brain imaging of freely moving sub...

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Autores principales: Bauer, Christopher E., Brefczynski‐Lewis, Julie, Marano, Gary, Mandich, Mary‐Beth, Stolin, Alexander, Martone, Peter, Lewis, James W., Jaliparthi, Gangadhar, Raylman, Raymond R., Majewski, Stan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036439/
https://www.ncbi.nlm.nih.gov/pubmed/27688946
http://dx.doi.org/10.1002/brb3.530
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author Bauer, Christopher E.
Brefczynski‐Lewis, Julie
Marano, Gary
Mandich, Mary‐Beth
Stolin, Alexander
Martone, Peter
Lewis, James W.
Jaliparthi, Gangadhar
Raylman, Raymond R.
Majewski, Stan
author_facet Bauer, Christopher E.
Brefczynski‐Lewis, Julie
Marano, Gary
Mandich, Mary‐Beth
Stolin, Alexander
Martone, Peter
Lewis, James W.
Jaliparthi, Gangadhar
Raylman, Raymond R.
Majewski, Stan
author_sort Bauer, Christopher E.
collection PubMed
description BACKGROUND: Positron Emission Tomography (PET) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain‐dedicated imaging. Our team has explored the concept of wearable PET imagers which could provide functional brain imaging of freely moving subjects. To test feasibility and determine future considerations for development, we built a rudimentary proof‐of‐concept prototype (Helmet_PET) and conducted tests in phantoms and four human volunteers. METHODS: Twelve Silicon Photomultiplier‐based detectors were assembled in a ring with exterior weight support and an interior mechanism that could be adjustably fitted to the head. We conducted brain phantom tests as well as scanned four patients scheduled for diagnostic F(18‐) FDG PET/CT imaging. For human subjects the imager was angled such that field of view included basal ganglia and visual cortex to test for typical resting‐state pattern. Imaging in two subjects was performed ~4 hr after PET/CT imaging to simulate lower injected F(18‐) FDG dose by taking advantage of the natural radioactive decay of the tracer (F(18) half‐life of 110 min), with an estimated imaging dosage of 25% of the standard. RESULTS: We found that imaging with a simple lightweight ring of detectors was feasible using a fraction of the standard radioligand dose. Activity levels in the human participants were quantitatively similar to standard PET in a set of anatomical ROIs. Typical resting‐state brain pattern activation was demonstrated even in a 1 min scan of active head rotation. CONCLUSION: To our knowledge, this is the first demonstration of imaging a human subject with a novel wearable PET imager that moves with robust head movements. We discuss potential research and clinical applications that will drive the design of a fully functional device. Designs will need to consider trade‐offs between a low weight device with high mobility and a heavier device with greater sensitivity and larger field of view.
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spelling pubmed-50364392016-09-29 Concept of an upright wearable positron emission tomography imager in humans Bauer, Christopher E. Brefczynski‐Lewis, Julie Marano, Gary Mandich, Mary‐Beth Stolin, Alexander Martone, Peter Lewis, James W. Jaliparthi, Gangadhar Raylman, Raymond R. Majewski, Stan Brain Behav Original Research BACKGROUND: Positron Emission Tomography (PET) is traditionally used to image patients in restrictive positions, with few devices allowing for upright, brain‐dedicated imaging. Our team has explored the concept of wearable PET imagers which could provide functional brain imaging of freely moving subjects. To test feasibility and determine future considerations for development, we built a rudimentary proof‐of‐concept prototype (Helmet_PET) and conducted tests in phantoms and four human volunteers. METHODS: Twelve Silicon Photomultiplier‐based detectors were assembled in a ring with exterior weight support and an interior mechanism that could be adjustably fitted to the head. We conducted brain phantom tests as well as scanned four patients scheduled for diagnostic F(18‐) FDG PET/CT imaging. For human subjects the imager was angled such that field of view included basal ganglia and visual cortex to test for typical resting‐state pattern. Imaging in two subjects was performed ~4 hr after PET/CT imaging to simulate lower injected F(18‐) FDG dose by taking advantage of the natural radioactive decay of the tracer (F(18) half‐life of 110 min), with an estimated imaging dosage of 25% of the standard. RESULTS: We found that imaging with a simple lightweight ring of detectors was feasible using a fraction of the standard radioligand dose. Activity levels in the human participants were quantitatively similar to standard PET in a set of anatomical ROIs. Typical resting‐state brain pattern activation was demonstrated even in a 1 min scan of active head rotation. CONCLUSION: To our knowledge, this is the first demonstration of imaging a human subject with a novel wearable PET imager that moves with robust head movements. We discuss potential research and clinical applications that will drive the design of a fully functional device. Designs will need to consider trade‐offs between a low weight device with high mobility and a heavier device with greater sensitivity and larger field of view. John Wiley and Sons Inc. 2016-08-05 /pmc/articles/PMC5036439/ /pubmed/27688946 http://dx.doi.org/10.1002/brb3.530 Text en © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Bauer, Christopher E.
Brefczynski‐Lewis, Julie
Marano, Gary
Mandich, Mary‐Beth
Stolin, Alexander
Martone, Peter
Lewis, James W.
Jaliparthi, Gangadhar
Raylman, Raymond R.
Majewski, Stan
Concept of an upright wearable positron emission tomography imager in humans
title Concept of an upright wearable positron emission tomography imager in humans
title_full Concept of an upright wearable positron emission tomography imager in humans
title_fullStr Concept of an upright wearable positron emission tomography imager in humans
title_full_unstemmed Concept of an upright wearable positron emission tomography imager in humans
title_short Concept of an upright wearable positron emission tomography imager in humans
title_sort concept of an upright wearable positron emission tomography imager in humans
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036439/
https://www.ncbi.nlm.nih.gov/pubmed/27688946
http://dx.doi.org/10.1002/brb3.530
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