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Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder

BACKGROUND: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV)...

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Autores principales: Asoglu, Mehmet, Aslan, Mehmet, Imre, Okan, Kivrak, Yuksel, Akil, Oznur, Savik, Emin, Buyukaslan, Hasan, Fedai, Ulker, Altındag, Abdurrahman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036575/
https://www.ncbi.nlm.nih.gov/pubmed/27703361
http://dx.doi.org/10.2147/NDT.S111108
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author Asoglu, Mehmet
Aslan, Mehmet
Imre, Okan
Kivrak, Yuksel
Akil, Oznur
Savik, Emin
Buyukaslan, Hasan
Fedai, Ulker
Altındag, Abdurrahman
author_facet Asoglu, Mehmet
Aslan, Mehmet
Imre, Okan
Kivrak, Yuksel
Akil, Oznur
Savik, Emin
Buyukaslan, Hasan
Fedai, Ulker
Altındag, Abdurrahman
author_sort Asoglu, Mehmet
collection PubMed
description BACKGROUND: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV) in patients with panic disorder (PD) are both limited and controversial. Herein, we aimed to evaluate, for the first time, the red cell distribution width (RDW) levels combined with MPV levels in patients with PD. PATIENTS AND METHODS: Between January 2012 and June 2015, data of 30 treatment-naïve patients (16 females, 14 males; mean age: 37±10 years; range: 18–59 years) who were diagnosed with PD and 25 age- and sex-matched healthy volunteers (10 females, 15 males; mean age: 36±13 years; range: 18–59 years) (control group) were retrospectively analyzed. The white blood cell count (WBC), MPV, and RDW levels were measured in both groups. RESULTS: The mean WBC, MPV, and RDW levels were 9,173.03±2,400.31/mm(3), 8.19±1.13 fl, and 12.47±1.14%, respectively, in the PD group. These values were found to be 7,090.24±1,032.61, 6.85±0.67, and 11.63±0.85, respectively, in the healthy controls. The WBC, MPV, and RDW levels were significantly higher in the patients with PD compared to the healthy controls (P=0.001, P=0.001, and P=0.003, respectively). However, there was no significant difference in the platelet number between the patients with PD and healthy controls (P>0.05). CONCLUSION: Our study results are the first to demonstrate that the RDW levels combined with MPV levels significantly increase among patients with PD. We believe that increased RDW and MPV levels can be used as a novel marker for PD.
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spelling pubmed-50365752016-10-04 Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder Asoglu, Mehmet Aslan, Mehmet Imre, Okan Kivrak, Yuksel Akil, Oznur Savik, Emin Buyukaslan, Hasan Fedai, Ulker Altındag, Abdurrahman Neuropsychiatr Dis Treat Original Research BACKGROUND: As the relationship between psychological stress and platelet activation has been widely studied in recent years, activated platelets lead to certain biochemical changes, which occur in the brain in patients with mental disorders. However, data relating to the mean platelet volume (MPV) in patients with panic disorder (PD) are both limited and controversial. Herein, we aimed to evaluate, for the first time, the red cell distribution width (RDW) levels combined with MPV levels in patients with PD. PATIENTS AND METHODS: Between January 2012 and June 2015, data of 30 treatment-naïve patients (16 females, 14 males; mean age: 37±10 years; range: 18–59 years) who were diagnosed with PD and 25 age- and sex-matched healthy volunteers (10 females, 15 males; mean age: 36±13 years; range: 18–59 years) (control group) were retrospectively analyzed. The white blood cell count (WBC), MPV, and RDW levels were measured in both groups. RESULTS: The mean WBC, MPV, and RDW levels were 9,173.03±2,400.31/mm(3), 8.19±1.13 fl, and 12.47±1.14%, respectively, in the PD group. These values were found to be 7,090.24±1,032.61, 6.85±0.67, and 11.63±0.85, respectively, in the healthy controls. The WBC, MPV, and RDW levels were significantly higher in the patients with PD compared to the healthy controls (P=0.001, P=0.001, and P=0.003, respectively). However, there was no significant difference in the platelet number between the patients with PD and healthy controls (P>0.05). CONCLUSION: Our study results are the first to demonstrate that the RDW levels combined with MPV levels significantly increase among patients with PD. We believe that increased RDW and MPV levels can be used as a novel marker for PD. Dove Medical Press 2016-09-22 /pmc/articles/PMC5036575/ /pubmed/27703361 http://dx.doi.org/10.2147/NDT.S111108 Text en © 2016 Asoglu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Asoglu, Mehmet
Aslan, Mehmet
Imre, Okan
Kivrak, Yuksel
Akil, Oznur
Savik, Emin
Buyukaslan, Hasan
Fedai, Ulker
Altındag, Abdurrahman
Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_full Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_fullStr Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_full_unstemmed Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_short Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
title_sort mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036575/
https://www.ncbi.nlm.nih.gov/pubmed/27703361
http://dx.doi.org/10.2147/NDT.S111108
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