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Editor’s Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response
Protein aggregation is associated with enhanced immunogenicity of biotherapeutics. As a result, regulatory guidelines recommend screening for aggregation during bioprocessing. However, the mechanisms underlying the enhanced immunogenicity of aggregates are poorly understood. In the investigations de...
Autores principales: | Ratanji, Kirsty D., Dearman, Rebecca J., Kimber, Ian, Thorpe, Robin, Wadhwa, Meenu, Derrick, Jeremy P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036615/ https://www.ncbi.nlm.nih.gov/pubmed/27370416 http://dx.doi.org/10.1093/toxsci/kfw121 |
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