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Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells

The androgen receptor antagonist, flutamide, is strongly associated with idiosyncratic drug-induced liver injury (DILI). Following administration, flutamide undergoes extensive first-pass metabolism to its primary metabolite, 2-hydroxyflutamide. Flutamide is a known mitochondrial toxicant; however t...

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Detalles Bibliográficos
Autores principales:	Ball, Amy L., Kamalian, Laleh, Alfirevic, Ana, Lyon, Jonathan J., Chadwick, Amy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Metabolite of Flutamide Causes Mitochondrial Dysfunction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036617/ https://www.ncbi.nlm.nih.gov/pubmed/27413113 http://dx.doi.org/10.1093/toxsci/kfw126

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