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Ubiquity of log-normal distributions in intra-cellular reaction dynamics

The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was...

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Detalles Bibliográficos
Autores principales: Furusawa, Chikara, Suzuki, Takao, Kashiwagi, Akiko, Yomo, Tetsuya, Kaneko, Kunihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036630/
https://www.ncbi.nlm.nih.gov/pubmed/27857550
http://dx.doi.org/10.2142/biophysics.1.25
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author Furusawa, Chikara
Suzuki, Takao
Kashiwagi, Akiko
Yomo, Tetsuya
Kaneko, Kunihiko
author_facet Furusawa, Chikara
Suzuki, Takao
Kashiwagi, Akiko
Yomo, Tetsuya
Kaneko, Kunihiko
author_sort Furusawa, Chikara
collection PubMed
description The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was found to be linear. The ubiquity of these laws was explored both theoretically and experimentally. By means of a model with a catalytic reaction network, the laws were shown to exist near a critical state with efficient self-reproduction. Additionally, by measuring distributions of fluorescent proteins in bacteria cells, the ubiquity of log-normal distribution of protein abundances was confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed.
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spelling pubmed-50366302016-11-17 Ubiquity of log-normal distributions in intra-cellular reaction dynamics Furusawa, Chikara Suzuki, Takao Kashiwagi, Akiko Yomo, Tetsuya Kaneko, Kunihiko Biophysics (Nagoya-shi) Articles The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was found to be linear. The ubiquity of these laws was explored both theoretically and experimentally. By means of a model with a catalytic reaction network, the laws were shown to exist near a critical state with efficient self-reproduction. Additionally, by measuring distributions of fluorescent proteins in bacteria cells, the ubiquity of log-normal distribution of protein abundances was confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed. The Biophysical Society of Japan (BSJ) 2005-04-21 /pmc/articles/PMC5036630/ /pubmed/27857550 http://dx.doi.org/10.2142/biophysics.1.25 Text en 2005 © The Biophysical Society of Japan
spellingShingle Articles
Furusawa, Chikara
Suzuki, Takao
Kashiwagi, Akiko
Yomo, Tetsuya
Kaneko, Kunihiko
Ubiquity of log-normal distributions in intra-cellular reaction dynamics
title Ubiquity of log-normal distributions in intra-cellular reaction dynamics
title_full Ubiquity of log-normal distributions in intra-cellular reaction dynamics
title_fullStr Ubiquity of log-normal distributions in intra-cellular reaction dynamics
title_full_unstemmed Ubiquity of log-normal distributions in intra-cellular reaction dynamics
title_short Ubiquity of log-normal distributions in intra-cellular reaction dynamics
title_sort ubiquity of log-normal distributions in intra-cellular reaction dynamics
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036630/
https://www.ncbi.nlm.nih.gov/pubmed/27857550
http://dx.doi.org/10.2142/biophysics.1.25
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