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Ubiquity of log-normal distributions in intra-cellular reaction dynamics
The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Biophysical Society of Japan (BSJ)
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036630/ https://www.ncbi.nlm.nih.gov/pubmed/27857550 http://dx.doi.org/10.2142/biophysics.1.25 |
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author | Furusawa, Chikara Suzuki, Takao Kashiwagi, Akiko Yomo, Tetsuya Kaneko, Kunihiko |
author_facet | Furusawa, Chikara Suzuki, Takao Kashiwagi, Akiko Yomo, Tetsuya Kaneko, Kunihiko |
author_sort | Furusawa, Chikara |
collection | PubMed |
description | The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was found to be linear. The ubiquity of these laws was explored both theoretically and experimentally. By means of a model with a catalytic reaction network, the laws were shown to exist near a critical state with efficient self-reproduction. Additionally, by measuring distributions of fluorescent proteins in bacteria cells, the ubiquity of log-normal distribution of protein abundances was confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed. |
format | Online Article Text |
id | pubmed-5036630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | The Biophysical Society of Japan (BSJ) |
record_format | MEDLINE/PubMed |
spelling | pubmed-50366302016-11-17 Ubiquity of log-normal distributions in intra-cellular reaction dynamics Furusawa, Chikara Suzuki, Takao Kashiwagi, Akiko Yomo, Tetsuya Kaneko, Kunihiko Biophysics (Nagoya-shi) Articles The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was found to be linear. The ubiquity of these laws was explored both theoretically and experimentally. By means of a model with a catalytic reaction network, the laws were shown to exist near a critical state with efficient self-reproduction. Additionally, by measuring distributions of fluorescent proteins in bacteria cells, the ubiquity of log-normal distribution of protein abundances was confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed. The Biophysical Society of Japan (BSJ) 2005-04-21 /pmc/articles/PMC5036630/ /pubmed/27857550 http://dx.doi.org/10.2142/biophysics.1.25 Text en 2005 © The Biophysical Society of Japan |
spellingShingle | Articles Furusawa, Chikara Suzuki, Takao Kashiwagi, Akiko Yomo, Tetsuya Kaneko, Kunihiko Ubiquity of log-normal distributions in intra-cellular reaction dynamics |
title | Ubiquity of log-normal distributions in intra-cellular reaction dynamics |
title_full | Ubiquity of log-normal distributions in intra-cellular reaction dynamics |
title_fullStr | Ubiquity of log-normal distributions in intra-cellular reaction dynamics |
title_full_unstemmed | Ubiquity of log-normal distributions in intra-cellular reaction dynamics |
title_short | Ubiquity of log-normal distributions in intra-cellular reaction dynamics |
title_sort | ubiquity of log-normal distributions in intra-cellular reaction dynamics |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036630/ https://www.ncbi.nlm.nih.gov/pubmed/27857550 http://dx.doi.org/10.2142/biophysics.1.25 |
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