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Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population

Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association betw...

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Autores principales: Chen, Shuang, Guo, Xiaofan, Yu, Shasha, Sun, Guozhe, Yang, Hongmei, Li, Zhao, Sun, Yingxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036674/
https://www.ncbi.nlm.nih.gov/pubmed/27563918
http://dx.doi.org/10.3390/ijerph13090841
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author Chen, Shuang
Guo, Xiaofan
Yu, Shasha
Sun, Guozhe
Yang, Hongmei
Li, Zhao
Sun, Yingxian
author_facet Chen, Shuang
Guo, Xiaofan
Yu, Shasha
Sun, Guozhe
Yang, Hongmei
Li, Zhao
Sun, Yingxian
author_sort Chen, Shuang
collection PubMed
description Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (≥35 years of age) participated in this survey. Elevated ALT was defined as >40 U/L. SUA ≥ 7.0 mg/dL in males or ≥6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443–2.861 for men; OR: 2.045, 95% CI: 1.221–3.425 for women, both p < 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063–2.025 for men; OR: 1.721, 95% CI: 1.146–2.585 for women, both p < 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.
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spelling pubmed-50366742016-09-29 Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population Chen, Shuang Guo, Xiaofan Yu, Shasha Sun, Guozhe Yang, Hongmei Li, Zhao Sun, Yingxian Int J Environ Res Public Health Article Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (≥35 years of age) participated in this survey. Elevated ALT was defined as >40 U/L. SUA ≥ 7.0 mg/dL in males or ≥6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443–2.861 for men; OR: 2.045, 95% CI: 1.221–3.425 for women, both p < 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063–2.025 for men; OR: 1.721, 95% CI: 1.146–2.585 for women, both p < 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults. MDPI 2016-08-24 2016-09 /pmc/articles/PMC5036674/ /pubmed/27563918 http://dx.doi.org/10.3390/ijerph13090841 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Shuang
Guo, Xiaofan
Yu, Shasha
Sun, Guozhe
Yang, Hongmei
Li, Zhao
Sun, Yingxian
Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
title Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
title_full Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
title_fullStr Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
title_full_unstemmed Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
title_short Association between Serum Uric Acid and Elevated Alanine Aminotransferase in the General Population
title_sort association between serum uric acid and elevated alanine aminotransferase in the general population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036674/
https://www.ncbi.nlm.nih.gov/pubmed/27563918
http://dx.doi.org/10.3390/ijerph13090841
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