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Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study

Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence of bacterial resistance, and not all countries have strict policies against the indiscriminate use of drugs in order to prevent resistance. This cross-sectional and...

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Autores principales: Rodrigues, Wellington Francisco, Miguel, Camila Botelho, Nogueira, Ana Paula Oliveira, Ueira-Vieira, Carlos, Paulino, Tony De Paiva, Soares, Siomar De Castro, De Resende, Elisabete Aparecida Mantovani Rodrigues, Lazo-Chica, Javier Emilio, Araújo, Marcelo Costa, Oliveira, Carlo José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036751/
https://www.ncbi.nlm.nih.gov/pubmed/27649224
http://dx.doi.org/10.3390/ijerph13090918
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author Rodrigues, Wellington Francisco
Miguel, Camila Botelho
Nogueira, Ana Paula Oliveira
Ueira-Vieira, Carlos
Paulino, Tony De Paiva
Soares, Siomar De Castro
De Resende, Elisabete Aparecida Mantovani Rodrigues
Lazo-Chica, Javier Emilio
Araújo, Marcelo Costa
Oliveira, Carlo José
author_facet Rodrigues, Wellington Francisco
Miguel, Camila Botelho
Nogueira, Ana Paula Oliveira
Ueira-Vieira, Carlos
Paulino, Tony De Paiva
Soares, Siomar De Castro
De Resende, Elisabete Aparecida Mantovani Rodrigues
Lazo-Chica, Javier Emilio
Araújo, Marcelo Costa
Oliveira, Carlo José
author_sort Rodrigues, Wellington Francisco
collection PubMed
description Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence of bacterial resistance, and not all countries have strict policies against the indiscriminate use of drugs in order to prevent resistance. This cross-sectional and retrospective study (2010–2015) aimed to evaluate the sensitivity and resistance of patient-derived E. coli to different drugs broadly used to treat urinary infections in Brazil: ampicillin + sulbactam, cephalothin, ciprofloxacin, norfloxacin, and nitrofurantoin. We obtained 1654 E. coli samples from ambulatory patients with disease symptoms of the urinary tract from a Brazilian public hospital. While all antibiotics were effective in killing E. coli to a large degree, nitrofurantoin was the most effective, with fewer samples exhibiting antibiotic resistance. We assessed the costs of generic and brand name versions of each antibiotic. Nitrofurantoin, the most effective antibiotic, was the cheapest, followed by the fluoroquinolones (ciprofloxacin and norfloxacin), ampicillin + sulbactam and, lastly, cephalothin. Finally, assessment of antibiotic resistance to fluoroquinolones over the study period and extrapolation of the data led to the conclusion that these antibiotics could no longer be effective against E. coli-based urinary infections in approximately 20 years if their indiscriminate use in empirical treatment continues.
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spelling pubmed-50367512016-09-29 Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study Rodrigues, Wellington Francisco Miguel, Camila Botelho Nogueira, Ana Paula Oliveira Ueira-Vieira, Carlos Paulino, Tony De Paiva Soares, Siomar De Castro De Resende, Elisabete Aparecida Mantovani Rodrigues Lazo-Chica, Javier Emilio Araújo, Marcelo Costa Oliveira, Carlo José Int J Environ Res Public Health Article Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence of bacterial resistance, and not all countries have strict policies against the indiscriminate use of drugs in order to prevent resistance. This cross-sectional and retrospective study (2010–2015) aimed to evaluate the sensitivity and resistance of patient-derived E. coli to different drugs broadly used to treat urinary infections in Brazil: ampicillin + sulbactam, cephalothin, ciprofloxacin, norfloxacin, and nitrofurantoin. We obtained 1654 E. coli samples from ambulatory patients with disease symptoms of the urinary tract from a Brazilian public hospital. While all antibiotics were effective in killing E. coli to a large degree, nitrofurantoin was the most effective, with fewer samples exhibiting antibiotic resistance. We assessed the costs of generic and brand name versions of each antibiotic. Nitrofurantoin, the most effective antibiotic, was the cheapest, followed by the fluoroquinolones (ciprofloxacin and norfloxacin), ampicillin + sulbactam and, lastly, cephalothin. Finally, assessment of antibiotic resistance to fluoroquinolones over the study period and extrapolation of the data led to the conclusion that these antibiotics could no longer be effective against E. coli-based urinary infections in approximately 20 years if their indiscriminate use in empirical treatment continues. MDPI 2016-09-15 2016-09 /pmc/articles/PMC5036751/ /pubmed/27649224 http://dx.doi.org/10.3390/ijerph13090918 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodrigues, Wellington Francisco
Miguel, Camila Botelho
Nogueira, Ana Paula Oliveira
Ueira-Vieira, Carlos
Paulino, Tony De Paiva
Soares, Siomar De Castro
De Resende, Elisabete Aparecida Mantovani Rodrigues
Lazo-Chica, Javier Emilio
Araújo, Marcelo Costa
Oliveira, Carlo José
Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
title Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
title_full Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
title_fullStr Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
title_full_unstemmed Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
title_short Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study
title_sort antibiotic resistance of bacteria involved in urinary infections in brazil: a cross-sectional and retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036751/
https://www.ncbi.nlm.nih.gov/pubmed/27649224
http://dx.doi.org/10.3390/ijerph13090918
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