Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy

A large subset of anaplastic large cell lymphoma (ALCL) patients harbour a somatic aberration in which anaplastic lymphoma kinase (ALK) is fused to nucleophosmin (NPM) resulting in a constitutively active signalling fusion protein, NPM-ALK. We computationally simulated the signalling network which m...

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Detalles Bibliográficos
Autores principales: Buetti-Dinh, Antoine, O’Hare, Thomas, Friedman, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036789/
https://www.ncbi.nlm.nih.gov/pubmed/27669408
http://dx.doi.org/10.1371/journal.pone.0163011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036789/
https://www.ncbi.nlm.nih.gov/pubmed/27669408
http://dx.doi.org/10.1371/journal.pone.0163011

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