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PFK15, a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer

PFKFB3 (6-phosphofructo-2-kinase) synthesizes fructose 2,6-bisphosphate (F2,6P(2)), which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), the rate-limiting enzyme of glycolysis. Overexpression of the PFKFB3 enzyme leads to high glycolytic metabolism, which is required for cancer cell...

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Detalles Bibliográficos
Autores principales:	Zhu, Wei, Ye, Liang, Zhang, Jianzhao, Yu, Pengfei, Wang, Hongbo, Ye, Zuguang, Tian, Jingwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036843/ https://www.ncbi.nlm.nih.gov/pubmed/27669567 http://dx.doi.org/10.1371/journal.pone.0163768

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