Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia

In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34(+) and more mature CD34(−) AML have heterogeneous immunophenotypes overlapping with normal stem/progenitor cells (SPC) b...

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Detalles Bibliográficos
Autores principales: Khan, Naeem, Hills, Robert K., Knapper, Steve, Steadman, Lora, Qureshi, Ushna, Rector, Jerrald L., Bradbury, Charlotte, Russell, Nigel H., Vyas, Paresh, Burnett, Alan K., Grimwade, David, Hole, Paul S., Freeman, Sylvie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036879/
https://www.ncbi.nlm.nih.gov/pubmed/27669008
http://dx.doi.org/10.1371/journal.pone.0163291

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