Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia

Fibroblast growth factor 23 (FGF23) is regulated by sustained phosphate supplementation and restriction. However, few studies have investigated FGF23 levels in patients with Fanconi syndrome. Therefore, we evaluated intact and C-terminal FGF23 and FGF23-associated parameters in four patients with Fa...

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Autores principales: Goto, Shunsuke, Fujii, Hideki, Kono, Keiji, Watanabe, Kentaro, Nakai, Kentaro, Nishi, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Fgf23
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036911/
https://www.ncbi.nlm.nih.gov/pubmed/27679714
http://dx.doi.org/10.1093/ckj/sfw086
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author Goto, Shunsuke
Fujii, Hideki
Kono, Keiji
Watanabe, Kentaro
Nakai, Kentaro
Nishi, Shinichi
author_facet Goto, Shunsuke
Fujii, Hideki
Kono, Keiji
Watanabe, Kentaro
Nakai, Kentaro
Nishi, Shinichi
author_sort Goto, Shunsuke
collection PubMed
description Fibroblast growth factor 23 (FGF23) is regulated by sustained phosphate supplementation and restriction. However, few studies have investigated FGF23 levels in patients with Fanconi syndrome. Therefore, we evaluated intact and C-terminal FGF23 and FGF23-associated parameters in four patients with Fanconi syndrome. Serum intact and C-terminal FGF23 levels were extremely low. Although serum phosphate and 1,25-dihydroxyvitamin D levels improved to or above the normal range within 1 year of treatment with oral phosphate and calcitriol, serum FGF23 levels remained low. Serum FGF23 levels in patients with Fanconi syndrome might be regulated by novel factors other than serum phosphate and 1,25-dihydroxyvitamin D levels.
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spelling pubmed-50369112016-09-27 Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia Goto, Shunsuke Fujii, Hideki Kono, Keiji Watanabe, Kentaro Nakai, Kentaro Nishi, Shinichi Clin Kidney J Fgf23 Fibroblast growth factor 23 (FGF23) is regulated by sustained phosphate supplementation and restriction. However, few studies have investigated FGF23 levels in patients with Fanconi syndrome. Therefore, we evaluated intact and C-terminal FGF23 and FGF23-associated parameters in four patients with Fanconi syndrome. Serum intact and C-terminal FGF23 levels were extremely low. Although serum phosphate and 1,25-dihydroxyvitamin D levels improved to or above the normal range within 1 year of treatment with oral phosphate and calcitriol, serum FGF23 levels remained low. Serum FGF23 levels in patients with Fanconi syndrome might be regulated by novel factors other than serum phosphate and 1,25-dihydroxyvitamin D levels. Oxford University Press 2016-10 2016-09-09 /pmc/articles/PMC5036911/ /pubmed/27679714 http://dx.doi.org/10.1093/ckj/sfw086 Text en © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Fgf23
Goto, Shunsuke
Fujii, Hideki
Kono, Keiji
Watanabe, Kentaro
Nakai, Kentaro
Nishi, Shinichi
Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia
title Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia
title_full Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia
title_fullStr Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia
title_full_unstemmed Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia
title_short Serum FGF23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin D levels in patients with Fanconi syndrome–induced hypophosphatemia
title_sort serum fgf23 levels may not be associated with serum phosphate and 1,25-dihydroxyvitamin d levels in patients with fanconi syndrome–induced hypophosphatemia
topic Fgf23
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036911/
https://www.ncbi.nlm.nih.gov/pubmed/27679714
http://dx.doi.org/10.1093/ckj/sfw086
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