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Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease
Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for cognitive reserve, would influence hippocampal structure in Alz...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036951/ https://www.ncbi.nlm.nih.gov/pubmed/27699079 http://dx.doi.org/10.14336/AD.2016.0305 |
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author | Baumgaertel, Johanna Haussmann, Robert Gruschwitz, Antonia Werner, Annett Osterrath, Antje Lange, Jan Donix, Katharina L. Linn, Jennifer Donix, Markus |
author_facet | Baumgaertel, Johanna Haussmann, Robert Gruschwitz, Antonia Werner, Annett Osterrath, Antje Lange, Jan Donix, Katharina L. Linn, Jennifer Donix, Markus |
author_sort | Baumgaertel, Johanna |
collection | PubMed |
description | Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for cognitive reserve, would influence hippocampal structure in Alzheimer’s disease patients, and whether apolipoprotein Eε4 (APOE4) carrier status and a first-degree family history of the disease would change a possible association. Fifty-eight Alzheimer’s disease patients underwent 3T magnetic resonance imaging. We applied a cortical unfolding approach to investigate individual subregions of the medial temporal lobe. Among patients homozygous for the APOE4 genotype or carrying both APOE4 and family history risks, lower education was associated with a thinner cortex in multiple medial temporal regions, including the hippocampus. Our data suggest that the years of formal education and genetic risks interact in their influence on hippocampal structure in Alzheimer’s disease patients. |
format | Online Article Text |
id | pubmed-5036951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-50369512016-10-04 Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease Baumgaertel, Johanna Haussmann, Robert Gruschwitz, Antonia Werner, Annett Osterrath, Antje Lange, Jan Donix, Katharina L. Linn, Jennifer Donix, Markus Aging Dis Original Article Genetic and environmental protective factors and risks modulate brain structure and function in neurodegenerative diseases and their preclinical stages. We wanted to investigate whether the years of formal education, a proxy measure for cognitive reserve, would influence hippocampal structure in Alzheimer’s disease patients, and whether apolipoprotein Eε4 (APOE4) carrier status and a first-degree family history of the disease would change a possible association. Fifty-eight Alzheimer’s disease patients underwent 3T magnetic resonance imaging. We applied a cortical unfolding approach to investigate individual subregions of the medial temporal lobe. Among patients homozygous for the APOE4 genotype or carrying both APOE4 and family history risks, lower education was associated with a thinner cortex in multiple medial temporal regions, including the hippocampus. Our data suggest that the years of formal education and genetic risks interact in their influence on hippocampal structure in Alzheimer’s disease patients. JKL International LLC 2016-10-01 /pmc/articles/PMC5036951/ /pubmed/27699079 http://dx.doi.org/10.14336/AD.2016.0305 Text en Copyright: © 2016 Baumgaertel J. et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Original Article Baumgaertel, Johanna Haussmann, Robert Gruschwitz, Antonia Werner, Annett Osterrath, Antje Lange, Jan Donix, Katharina L. Linn, Jennifer Donix, Markus Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease |
title | Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease |
title_full | Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease |
title_fullStr | Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease |
title_full_unstemmed | Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease |
title_short | Education and Genetic Risk Modulate Hippocampal Structure in Alzheimer’s Disease |
title_sort | education and genetic risk modulate hippocampal structure in alzheimer’s disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036951/ https://www.ncbi.nlm.nih.gov/pubmed/27699079 http://dx.doi.org/10.14336/AD.2016.0305 |
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