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Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue
Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037097/ https://www.ncbi.nlm.nih.gov/pubmed/27671016 http://dx.doi.org/10.1186/s11671-016-1650-z |
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author | Wang, Wei Li, Jian Liu, Ransheng Zhang, Aixu Yuan, Zhiyong |
author_facet | Wang, Wei Li, Jian Liu, Ransheng Zhang, Aixu Yuan, Zhiyong |
author_sort | Wang, Wei |
collection | PubMed |
description | Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au/PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au/PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au/PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors. |
format | Online Article Text |
id | pubmed-5037097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-50370972016-10-03 Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue Wang, Wei Li, Jian Liu, Ransheng Zhang, Aixu Yuan, Zhiyong Nanoscale Res Lett Nano Express Polyamidoamine (PAMAM)-entrapped Au nanoparticles were synthesized with distinct sizes to figure out the size effect of Au-based contrast agent on CT imaging of passively targeted tissues. Au/PAMAM nanoparticles were first synthesized with narrow distribution of particles size of 22.2 ± 3.1, 54.2 ± 3.7, and 104.9 ± 4.7 nm in diameters. Size effect leads no significant difference on X-ray attenuation when Au/PAMAM was ≤0.05 mol/L. For CT imaging of a tumor model, small Au/PAMAM were more easily internalized via endocytosis in the liver, leading to more obviously enhanced contrast. Similarly, contrast agents with small sizes were more effective in tumor imaging because of the enhanced permeability and retention effect. Overall, the particle size of Au/PAMAM heavily affected the efficiency of CT enhancement in imaging RES and tumors. Springer US 2016-09-26 /pmc/articles/PMC5037097/ /pubmed/27671016 http://dx.doi.org/10.1186/s11671-016-1650-z Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Nano Express Wang, Wei Li, Jian Liu, Ransheng Zhang, Aixu Yuan, Zhiyong Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue |
title | Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue |
title_full | Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue |
title_fullStr | Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue |
title_full_unstemmed | Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue |
title_short | Size effect of Au/PAMAM contrast agent on CT imaging of reticuloendothelial system and tumor tissue |
title_sort | size effect of au/pamam contrast agent on ct imaging of reticuloendothelial system and tumor tissue |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037097/ https://www.ncbi.nlm.nih.gov/pubmed/27671016 http://dx.doi.org/10.1186/s11671-016-1650-z |
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