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Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study

BACKGROUND: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in th...

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Autores principales: Chen, Zhiye, Chen, Xiaoyan, Liu, Mengqi, Liu, Shuangfeng, Shu, Siyun, Ma, Lin, Yu, Shengyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037100/
https://www.ncbi.nlm.nih.gov/pubmed/27670428
http://dx.doi.org/10.1186/s10194-016-0682-1
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author Chen, Zhiye
Chen, Xiaoyan
Liu, Mengqi
Liu, Shuangfeng
Shu, Siyun
Ma, Lin
Yu, Shengyuan
author_facet Chen, Zhiye
Chen, Xiaoyan
Liu, Mengqi
Liu, Shuangfeng
Shu, Siyun
Ma, Lin
Yu, Shengyuan
author_sort Chen, Zhiye
collection PubMed
description BACKGROUND: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI). METHODS: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC). RESULTS: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group. CONCLUSION: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.
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spelling pubmed-50371002016-10-03 Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study Chen, Zhiye Chen, Xiaoyan Liu, Mengqi Liu, Shuangfeng Shu, Siyun Ma, Lin Yu, Shengyuan J Headache Pain Research Article BACKGROUND: The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI). METHODS: Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC). RESULTS: Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group. CONCLUSION: This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation. Springer Milan 2016-09-26 /pmc/articles/PMC5037100/ /pubmed/27670428 http://dx.doi.org/10.1186/s10194-016-0682-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Chen, Zhiye
Chen, Xiaoyan
Liu, Mengqi
Liu, Shuangfeng
Shu, Siyun
Ma, Lin
Yu, Shengyuan
Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
title Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
title_full Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
title_fullStr Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
title_full_unstemmed Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
title_short Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
title_sort altered functional connectivity of the marginal division in migraine: a resting-state fmri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037100/
https://www.ncbi.nlm.nih.gov/pubmed/27670428
http://dx.doi.org/10.1186/s10194-016-0682-1
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