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Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report
Hepatic cirrhosis is commonly associated with hyperestrogenism. Previous studies have reported morphologic changes in benign and malignant prostate tissue exposed to estrogen or anti-androgens. To our knowledge, histopathologic features of prostatic adenocarcinoma in patients with cirrhosis have not...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037208/ https://www.ncbi.nlm.nih.gov/pubmed/27679759 http://dx.doi.org/10.1016/j.eucr.2016.08.004 |
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author | Skala, Stephanie L. Owens, Scott R. Xiao, Hong Bauman, Kristy A. Tomlins, Scott A. Chinnaiyan, Arul M. Shao, Lina Jentzen, Jeffrey M. Gordon, David Mehra, Rohit |
author_facet | Skala, Stephanie L. Owens, Scott R. Xiao, Hong Bauman, Kristy A. Tomlins, Scott A. Chinnaiyan, Arul M. Shao, Lina Jentzen, Jeffrey M. Gordon, David Mehra, Rohit |
author_sort | Skala, Stephanie L. |
collection | PubMed |
description | Hepatic cirrhosis is commonly associated with hyperestrogenism. Previous studies have reported morphologic changes in benign and malignant prostate tissue exposed to estrogen or anti-androgens. To our knowledge, histopathologic features of prostatic adenocarcinoma in patients with cirrhosis have not been well-reported. We present a case of incidental, but pathologically significant, prostatic adenocarcinoma detected on autopsy in a 67-year-old male patient with cirrhosis and spider angiomata. The morphologic and immunohistochemical features (including variable ERG expression) of the prostatic adenocarcinoma were consistent with hormone exposure related changes, suggesting that cirrhosis-induced elevated estrogen-to-testosterone ratio and exogenous hormone therapy might induce similar phenotypes. |
format | Online Article Text |
id | pubmed-5037208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-50372082016-09-27 Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report Skala, Stephanie L. Owens, Scott R. Xiao, Hong Bauman, Kristy A. Tomlins, Scott A. Chinnaiyan, Arul M. Shao, Lina Jentzen, Jeffrey M. Gordon, David Mehra, Rohit Urol Case Rep Oncology Hepatic cirrhosis is commonly associated with hyperestrogenism. Previous studies have reported morphologic changes in benign and malignant prostate tissue exposed to estrogen or anti-androgens. To our knowledge, histopathologic features of prostatic adenocarcinoma in patients with cirrhosis have not been well-reported. We present a case of incidental, but pathologically significant, prostatic adenocarcinoma detected on autopsy in a 67-year-old male patient with cirrhosis and spider angiomata. The morphologic and immunohistochemical features (including variable ERG expression) of the prostatic adenocarcinoma were consistent with hormone exposure related changes, suggesting that cirrhosis-induced elevated estrogen-to-testosterone ratio and exogenous hormone therapy might induce similar phenotypes. Elsevier 2016-09-23 /pmc/articles/PMC5037208/ /pubmed/27679759 http://dx.doi.org/10.1016/j.eucr.2016.08.004 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology Skala, Stephanie L. Owens, Scott R. Xiao, Hong Bauman, Kristy A. Tomlins, Scott A. Chinnaiyan, Arul M. Shao, Lina Jentzen, Jeffrey M. Gordon, David Mehra, Rohit Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report |
title | Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report |
title_full | Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report |
title_fullStr | Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report |
title_full_unstemmed | Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report |
title_short | Prostatic Adenocarcinoma With Hormone Exposure Related Changes in a Patient With Hepatic Cirrhosis – Value of Autopsy in a Case Report |
title_sort | prostatic adenocarcinoma with hormone exposure related changes in a patient with hepatic cirrhosis – value of autopsy in a case report |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037208/ https://www.ncbi.nlm.nih.gov/pubmed/27679759 http://dx.doi.org/10.1016/j.eucr.2016.08.004 |
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