Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs

Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p < 0.05) and showed clinical signs of improve...

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Autores principales: Ahn, Jin-Ok, Li, Qiang, Lee, Young-Heun, Han, Sei-Myoung, Hwang, Cheol-Yong, Youn, Hwa-Young, Chung, Jin-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037314/
https://www.ncbi.nlm.nih.gov/pubmed/26726023
http://dx.doi.org/10.4142/jvs.2016.17.3.431
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author Ahn, Jin-Ok
Li, Qiang
Lee, Young-Heun
Han, Sei-Myoung
Hwang, Cheol-Yong
Youn, Hwa-Young
Chung, Jin-Young
author_facet Ahn, Jin-Ok
Li, Qiang
Lee, Young-Heun
Han, Sei-Myoung
Hwang, Cheol-Yong
Youn, Hwa-Young
Chung, Jin-Young
author_sort Ahn, Jin-Ok
collection PubMed
description Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p < 0.05) and showed clinical signs of improvement. However, there were no clinical signs of improvement in two dogs, even though the ammonia level decreased. Conversely, the clinical signs of the control group also improved and the ammonia level decreased, although these changes were not significant (p > 0.05). These results suggest that LOLA is an effective drug to treat hyperammonemia in veterinary medicine.
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spelling pubmed-50373142016-09-29 Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs Ahn, Jin-Ok Li, Qiang Lee, Young-Heun Han, Sei-Myoung Hwang, Cheol-Yong Youn, Hwa-Young Chung, Jin-Young J Vet Sci Case Report Seventeen dogs were treated with L-ornithin-L-aspartate (LOLA; experimental group). Three dogs were treated with lactulose recognized therapy (control group). Following LOLA administration, 15 dogs experienced a significant decrease in ammonia level (p < 0.05) and showed clinical signs of improvement. However, there were no clinical signs of improvement in two dogs, even though the ammonia level decreased. Conversely, the clinical signs of the control group also improved and the ammonia level decreased, although these changes were not significant (p > 0.05). These results suggest that LOLA is an effective drug to treat hyperammonemia in veterinary medicine. The Korean Society of Veterinary Science 2016-09 2016-09-20 /pmc/articles/PMC5037314/ /pubmed/26726023 http://dx.doi.org/10.4142/jvs.2016.17.3.431 Text en © 2016 The Korean Society of Veterinary Science. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ahn, Jin-Ok
Li, Qiang
Lee, Young-Heun
Han, Sei-Myoung
Hwang, Cheol-Yong
Youn, Hwa-Young
Chung, Jin-Young
Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
title Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
title_full Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
title_fullStr Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
title_full_unstemmed Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
title_short Hyperammonemic hepatic encephalopathy management through L-ornithin-L-aspartate administration in dogs
title_sort hyperammonemic hepatic encephalopathy management through l-ornithin-l-aspartate administration in dogs
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037314/
https://www.ncbi.nlm.nih.gov/pubmed/26726023
http://dx.doi.org/10.4142/jvs.2016.17.3.431
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