Blood flow boosts BMP signaling to keep vessels in shape

Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress...

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Detalles Bibliográficos
Autores principales: Franco, Claudio A., Gerhardt, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037414/
https://www.ncbi.nlm.nih.gov/pubmed/27672213
http://dx.doi.org/10.1083/jcb.201609038
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author Franco, Claudio A.
Gerhardt, Holger
author_facet Franco, Claudio A.
Gerhardt, Holger
author_sort Franco, Claudio A.
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description Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.
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spelling pubmed-50374142017-03-26 Blood flow boosts BMP signaling to keep vessels in shape Franco, Claudio A. Gerhardt, Holger J Cell Biol Commentary Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence. The Rockefeller University Press 2016-09-26 /pmc/articles/PMC5037414/ /pubmed/27672213 http://dx.doi.org/10.1083/jcb.201609038 Text en © 2016 Franco and Gerhardt This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Franco, Claudio A.
Gerhardt, Holger
Blood flow boosts BMP signaling to keep vessels in shape
title Blood flow boosts BMP signaling to keep vessels in shape
title_full Blood flow boosts BMP signaling to keep vessels in shape
title_fullStr Blood flow boosts BMP signaling to keep vessels in shape
title_full_unstemmed Blood flow boosts BMP signaling to keep vessels in shape
title_short Blood flow boosts BMP signaling to keep vessels in shape
title_sort blood flow boosts bmp signaling to keep vessels in shape
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037414/
https://www.ncbi.nlm.nih.gov/pubmed/27672213
http://dx.doi.org/10.1083/jcb.201609038
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