High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1

Glycolate oxidase (GO) and alanine:glyoxylate aminotransferase (AGT) are both involved in the peroxisomal glyoxylate pathway. Deficiency in AGT function causes the accumulation of intracellular oxalate and the primary hyperoxaluria type 1 (PH1). AGT enhancers or GO inhibitors may restore the abnorma...

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Detalles Bibliográficos
Autores principales: Wang, Mengqiao, Xu, Miao, Long, Yan, Fargue, Sonia, Southall, Noel, Hu, Xin, McKew, John C., Danpure, Christopher J., Zheng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037430/
https://www.ncbi.nlm.nih.gov/pubmed/27670739
http://dx.doi.org/10.1038/srep34060

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