Cargando…
The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein
Between 6% and 11% of the world’s population suffers from malnutrition or undernutrition associated with poverty, aging or long-term hospitalization. The present work examined the effect of different types of proteins on the mechanistic target of rapamycin (mTORC1)-signaling pathway in: (1) healthy;...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037558/ https://www.ncbi.nlm.nih.gov/pubmed/27657118 http://dx.doi.org/10.3390/nu8090573 |
_version_ | 1782455762834948096 |
---|---|
author | Márquez-Mota, Claudia C. Rodriguez-Gaytan, Cinthya Adjibade, Pauline Mazroui, Rachid Gálvez, Amanda Granados, Omar Tovar, Armando R. Torres, Nimbe |
author_facet | Márquez-Mota, Claudia C. Rodriguez-Gaytan, Cinthya Adjibade, Pauline Mazroui, Rachid Gálvez, Amanda Granados, Omar Tovar, Armando R. Torres, Nimbe |
author_sort | Márquez-Mota, Claudia C. |
collection | PubMed |
description | Between 6% and 11% of the world’s population suffers from malnutrition or undernutrition associated with poverty, aging or long-term hospitalization. The present work examined the effect of different types of proteins on the mechanistic target of rapamycin (mTORC1)-signaling pathway in: (1) healthy; and (2) protein restricted rats. (1) In total, 200 rats were divided into eight groups and fed one of the following diets: 20% casein (C), soy (S), black bean (B), B + Corn (BCr), Pea (P), spirulina (Sp), sesame (Se) or Corn (Cr). Rats fed C or BCr had the highest body weight gain; rats fed BCr had the highest pS6K1/S6K1 ratio; rats fed B, BCr or P had the highest eIF4G expression; (2) In total, 84 rats were fed 0.5% C for 21 day and protein rehabilitated with different proteins. The S, soy + Corn (SCr) and BCr groups had the highest body weight gain. Rats fed SCr and BCr had the highest eIF4G expression and liver polysome formation. These findings suggest that the quality of the dietary proteins modulate the mTORC1-signaling pathway. In conclusion, the combination of BCr or SCr are the best proteins for dietary protein rehabilitation due to the significant increase in body weight, activation of the mTORC1-signaling pathway in liver and muscle, and liver polysome formation. |
format | Online Article Text |
id | pubmed-5037558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50375582016-10-15 The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein Márquez-Mota, Claudia C. Rodriguez-Gaytan, Cinthya Adjibade, Pauline Mazroui, Rachid Gálvez, Amanda Granados, Omar Tovar, Armando R. Torres, Nimbe Nutrients Article Between 6% and 11% of the world’s population suffers from malnutrition or undernutrition associated with poverty, aging or long-term hospitalization. The present work examined the effect of different types of proteins on the mechanistic target of rapamycin (mTORC1)-signaling pathway in: (1) healthy; and (2) protein restricted rats. (1) In total, 200 rats were divided into eight groups and fed one of the following diets: 20% casein (C), soy (S), black bean (B), B + Corn (BCr), Pea (P), spirulina (Sp), sesame (Se) or Corn (Cr). Rats fed C or BCr had the highest body weight gain; rats fed BCr had the highest pS6K1/S6K1 ratio; rats fed B, BCr or P had the highest eIF4G expression; (2) In total, 84 rats were fed 0.5% C for 21 day and protein rehabilitated with different proteins. The S, soy + Corn (SCr) and BCr groups had the highest body weight gain. Rats fed SCr and BCr had the highest eIF4G expression and liver polysome formation. These findings suggest that the quality of the dietary proteins modulate the mTORC1-signaling pathway. In conclusion, the combination of BCr or SCr are the best proteins for dietary protein rehabilitation due to the significant increase in body weight, activation of the mTORC1-signaling pathway in liver and muscle, and liver polysome formation. MDPI 2016-09-20 /pmc/articles/PMC5037558/ /pubmed/27657118 http://dx.doi.org/10.3390/nu8090573 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Márquez-Mota, Claudia C. Rodriguez-Gaytan, Cinthya Adjibade, Pauline Mazroui, Rachid Gálvez, Amanda Granados, Omar Tovar, Armando R. Torres, Nimbe The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein |
title | The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein |
title_full | The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein |
title_fullStr | The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein |
title_full_unstemmed | The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein |
title_short | The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein |
title_sort | mtorc1-signaling pathway and hepatic polyribosome profile are enhanced after the recovery of a protein restricted diet by a combination of soy or black bean with corn protein |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037558/ https://www.ncbi.nlm.nih.gov/pubmed/27657118 http://dx.doi.org/10.3390/nu8090573 |
work_keys_str_mv | AT marquezmotaclaudiac themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT rodriguezgaytancinthya themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT adjibadepauline themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT mazrouirachid themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT galvezamanda themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT granadosomar themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT tovararmandor themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT torresnimbe themtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT marquezmotaclaudiac mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT rodriguezgaytancinthya mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT adjibadepauline mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT mazrouirachid mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT galvezamanda mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT granadosomar mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT tovararmandor mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein AT torresnimbe mtorc1signalingpathwayandhepaticpolyribosomeprofileareenhancedaftertherecoveryofaproteinrestricteddietbyacombinationofsoyorblackbeanwithcornprotein |