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Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke
We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute ischemic stroke of the anterior circulation admitted to two Cen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037662/ https://www.ncbi.nlm.nih.gov/pubmed/27563874 http://dx.doi.org/10.3390/ijms17091382 |
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author | Pikija, Slaven Magdic, Jozef Lukic, Anita Schreiber, Catharina Mutzenbach, Johannes Sebastian McCoy, Mark R. Sellner, Johann |
author_facet | Pikija, Slaven Magdic, Jozef Lukic, Anita Schreiber, Catharina Mutzenbach, Johannes Sebastian McCoy, Mark R. Sellner, Johann |
author_sort | Pikija, Slaven |
collection | PubMed |
description | We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute ischemic stroke of the anterior circulation admitted to two Central European stroke centers. The acquisition of non-contrast enhanced CT (NECT) and CT angiography (CTA) within 4.5 h of symptom onset was obligatory. We assessed the site of MCA occlusion as well as density, area, and length of the clot in 150 patients. The Hounsfield unit values for the clot were divided with contralateral MCA segment to yield relative Hounsfield Unit ratio (rHU). The site of the vessel occlusion (M1 vs. M2) and antiplatelet usage, but not stroke etiology, significantly influenced rHU. We found an inverse correlation of rHU with erythrocyte count (p < 0.001). The multivariate analysis revealed that a higher rHU (i.e., clot being more hyperdense) was more likely with the use of antiplatelets (OR 4.24, CI 1.10–16.31, p = 0.036). Erythrocyte (OR 0.18, CI 0.05–0.55, p = 0.003), and thrombocyte counts (OR 0.99, CI 0.98–0.99, p = 0.029) were associated with odds for more hypodense clots (lower rHU). Our study disclosed that antiplatelet therapy impacts the composition of intracranial clots of the anterior circulation. |
format | Online Article Text |
id | pubmed-5037662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-50376622016-09-29 Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke Pikija, Slaven Magdic, Jozef Lukic, Anita Schreiber, Catharina Mutzenbach, Johannes Sebastian McCoy, Mark R. Sellner, Johann Int J Mol Sci Article We explored whether clot density in middle cerebral artery (MCA) occlusion is related to clinical variables, stroke etiology, blood constituents, and prestroke medication. We performed a retrospective chart review of patients with acute ischemic stroke of the anterior circulation admitted to two Central European stroke centers. The acquisition of non-contrast enhanced CT (NECT) and CT angiography (CTA) within 4.5 h of symptom onset was obligatory. We assessed the site of MCA occlusion as well as density, area, and length of the clot in 150 patients. The Hounsfield unit values for the clot were divided with contralateral MCA segment to yield relative Hounsfield Unit ratio (rHU). The site of the vessel occlusion (M1 vs. M2) and antiplatelet usage, but not stroke etiology, significantly influenced rHU. We found an inverse correlation of rHU with erythrocyte count (p < 0.001). The multivariate analysis revealed that a higher rHU (i.e., clot being more hyperdense) was more likely with the use of antiplatelets (OR 4.24, CI 1.10–16.31, p = 0.036). Erythrocyte (OR 0.18, CI 0.05–0.55, p = 0.003), and thrombocyte counts (OR 0.99, CI 0.98–0.99, p = 0.029) were associated with odds for more hypodense clots (lower rHU). Our study disclosed that antiplatelet therapy impacts the composition of intracranial clots of the anterior circulation. MDPI 2016-08-23 /pmc/articles/PMC5037662/ /pubmed/27563874 http://dx.doi.org/10.3390/ijms17091382 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pikija, Slaven Magdic, Jozef Lukic, Anita Schreiber, Catharina Mutzenbach, Johannes Sebastian McCoy, Mark R. Sellner, Johann Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke |
title | Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke |
title_full | Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke |
title_fullStr | Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke |
title_full_unstemmed | Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke |
title_short | Antiplatelet Usage Impacts Clot Density in Acute Anterior Circulation Ischemic Stroke |
title_sort | antiplatelet usage impacts clot density in acute anterior circulation ischemic stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037662/ https://www.ncbi.nlm.nih.gov/pubmed/27563874 http://dx.doi.org/10.3390/ijms17091382 |
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