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Hypoxia Suppresses Spontaneous Mineralization and Osteogenic Differentiation of Mesenchymal Stem Cells via IGFBP3 Up-Regulation

Hypoxia has diverse stimulatory effects on human adipose-derived stem cells (ASCs). In the present study, we investigated whether hypoxic culture conditions (2% O(2)) suppress spontaneous mineralization and osteogenic differentiation of ASCs. We also investigated signaling pathways and molecular mec...

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Detalles Bibliográficos
Autores principales:	Kim, Ji Hye, Yoon, Sei Mee, Song, Sun U., Park, Sang Gyu, Kim, Won-Serk, Park, In Guk, Lee, Jinu, Sung, Jong-Hyuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037669/ https://www.ncbi.nlm.nih.gov/pubmed/27563882 http://dx.doi.org/10.3390/ijms17091389

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