Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells

Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in ter...

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Autores principales: Choudhry, Qaisra Naheed, Kim, Mi Jeong, Kim, Tae Gyun, Pan, Jeong Hoon, Kim, Jun Ho, Park, Sung Jin, Lee, Jin Hyup, Kim, Young Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037686/
https://www.ncbi.nlm.nih.gov/pubmed/27571071
http://dx.doi.org/10.3390/ijms17091406
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author Choudhry, Qaisra Naheed
Kim, Mi Jeong
Kim, Tae Gyun
Pan, Jeong Hoon
Kim, Jun Ho
Park, Sung Jin
Lee, Jin Hyup
Kim, Young Jun
author_facet Choudhry, Qaisra Naheed
Kim, Mi Jeong
Kim, Tae Gyun
Pan, Jeong Hoon
Kim, Jun Ho
Park, Sung Jin
Lee, Jin Hyup
Kim, Young Jun
author_sort Choudhry, Qaisra Naheed
collection PubMed
description Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E.
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spelling pubmed-50376862016-09-29 Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells Choudhry, Qaisra Naheed Kim, Mi Jeong Kim, Tae Gyun Pan, Jeong Hoon Kim, Jun Ho Park, Sung Jin Lee, Jin Hyup Kim, Young Jun Int J Mol Sci Article Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E. MDPI 2016-08-26 /pmc/articles/PMC5037686/ /pubmed/27571071 http://dx.doi.org/10.3390/ijms17091406 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choudhry, Qaisra Naheed
Kim, Mi Jeong
Kim, Tae Gyun
Pan, Jeong Hoon
Kim, Jun Ho
Park, Sung Jin
Lee, Jin Hyup
Kim, Young Jun
Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
title Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
title_full Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
title_fullStr Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
title_full_unstemmed Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
title_short Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells
title_sort saponin-based nanoemulsification improves the antioxidant properties of vitamin a and e in aml-12 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037686/
https://www.ncbi.nlm.nih.gov/pubmed/27571071
http://dx.doi.org/10.3390/ijms17091406
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