Intra-Peritoneal Administration of Mitochondrial DNA Provokes Acute Lung Injury and Systemic Inflammation via Toll-Like Receptor 9

The pathogenesis of sepsis is complex. Mitochondrial dysfunction, which is responsible for energy metabolism, intrinsic apoptotic pathway, oxidative stress, and systemic inflammatory responses, is closely related with severe sepsis induced death. Mitochondria DNA (mtDNA) contain un-methylated cytosi...

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Detalles Bibliográficos
Autores principales: Zhang, Lemeng, Deng, Songyun, Zhao, Shuangping, Ai, Yuhang, Zhang, Lina, Pan, Pinhua, Su, Xiaoli, Tan, Hongyi, Wu, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037704/
https://www.ncbi.nlm.nih.gov/pubmed/27589725
http://dx.doi.org/10.3390/ijms17091425

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