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Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori

The head, which performs many biological functions, is the most complicated structure of an insect. Development, locomotor behavior, food intake, environmental sensing, and signal transduction are all controlled by the insect’s head. As a well-studied insect in Lepidoptera, the silkworm head has an...

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Autores principales: Li, Yi, Wang, Xin, Chen, Quanmei, Hou, Yong, Xia, Qingyou, Zhao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037739/
https://www.ncbi.nlm.nih.gov/pubmed/27657048
http://dx.doi.org/10.3390/ijms17091460
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author Li, Yi
Wang, Xin
Chen, Quanmei
Hou, Yong
Xia, Qingyou
Zhao, Ping
author_facet Li, Yi
Wang, Xin
Chen, Quanmei
Hou, Yong
Xia, Qingyou
Zhao, Ping
author_sort Li, Yi
collection PubMed
description The head, which performs many biological functions, is the most complicated structure of an insect. Development, locomotor behavior, food intake, environmental sensing, and signal transduction are all controlled by the insect’s head. As a well-studied insect in Lepidoptera, the silkworm head has an additional function of spinning silk fibers. To understand which molecules are involved in these physiological activities, we performed a metabolomics analysis of silkworm heads. By integrating GC-MS and LC-MS/MS, 90 metabolites were identified in the larval heads of silkworms. These were classified into 13 categories, including amino acids, sugars, organic acids, nucleotides, alcohols, and fatty acids. Informatics analysis revealed that these metabolites are involved in cellular processes, environmental information processing, genetic information processing, human diseases, metabolism, organismal systems, and other pathways. The identified metabolites and pathways are involved in biological processes such as signal transduction, carbohydrate metabolism, endocrine activities, and sensory activities; reflecting the functions of various organs in silkworm heads. Thus, our findings provide references which elucidate the potential functions of the silkworm head and will be of great value for the metabolomics research of silkworms and other insects.
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spelling pubmed-50377392016-09-29 Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori Li, Yi Wang, Xin Chen, Quanmei Hou, Yong Xia, Qingyou Zhao, Ping Int J Mol Sci Article The head, which performs many biological functions, is the most complicated structure of an insect. Development, locomotor behavior, food intake, environmental sensing, and signal transduction are all controlled by the insect’s head. As a well-studied insect in Lepidoptera, the silkworm head has an additional function of spinning silk fibers. To understand which molecules are involved in these physiological activities, we performed a metabolomics analysis of silkworm heads. By integrating GC-MS and LC-MS/MS, 90 metabolites were identified in the larval heads of silkworms. These were classified into 13 categories, including amino acids, sugars, organic acids, nucleotides, alcohols, and fatty acids. Informatics analysis revealed that these metabolites are involved in cellular processes, environmental information processing, genetic information processing, human diseases, metabolism, organismal systems, and other pathways. The identified metabolites and pathways are involved in biological processes such as signal transduction, carbohydrate metabolism, endocrine activities, and sensory activities; reflecting the functions of various organs in silkworm heads. Thus, our findings provide references which elucidate the potential functions of the silkworm head and will be of great value for the metabolomics research of silkworms and other insects. MDPI 2016-09-20 /pmc/articles/PMC5037739/ /pubmed/27657048 http://dx.doi.org/10.3390/ijms17091460 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yi
Wang, Xin
Chen, Quanmei
Hou, Yong
Xia, Qingyou
Zhao, Ping
Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori
title Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori
title_full Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori
title_fullStr Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori
title_full_unstemmed Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori
title_short Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori
title_sort metabolomics analysis of the larval head of the silkworm, bombyx mori
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037739/
https://www.ncbi.nlm.nih.gov/pubmed/27657048
http://dx.doi.org/10.3390/ijms17091460
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