Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword

Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation. These insults elicit activation of cell cycle checkpoints, safeguard mechanisms that cells implement to correctly complete cell...

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Detalles Bibliográficos
Autores principales: Visconti, Roberta, Della Monica, Rosa, Grieco, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037895/
https://www.ncbi.nlm.nih.gov/pubmed/27670139
http://dx.doi.org/10.1186/s13046-016-0433-9

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