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DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion

MATERIAL AND METHODS: The study was of prospective-retrospective character. It was carried out at the AKH in Vienna (Austria), where 100 patients with focal liver lesions were included in the study. All patients underwent the routine MR sequences on appliances 1,5 and 3T (Siemens, Germany): T1, T2,...

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Autores principales: Jahic, Elma, Sofic, Amela, Selimovic, Azra Husic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AVICENA, d.o.o., Sarajevo 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037977/
https://www.ncbi.nlm.nih.gov/pubmed/27708485
http://dx.doi.org/10.5455/aim.2016.24.244-247
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author Jahic, Elma
Sofic, Amela
Selimovic, Azra Husic
author_facet Jahic, Elma
Sofic, Amela
Selimovic, Azra Husic
author_sort Jahic, Elma
collection PubMed
description MATERIAL AND METHODS: The study was of prospective-retrospective character. It was carried out at the AKH in Vienna (Austria), where 100 patients with focal liver lesions were included in the study. All patients underwent the routine MR sequences on appliances 1,5 and 3T (Siemens, Germany): T1, T2, HASTE, VIBE, and a DWI with three b values (b 50, b 300 b 600 s / mm(2)) and ADC map with ROI (regions of interest). The numerical value of ADC map was calculated, where n = 100 liver lesions, by two independent radiologists. RESULTS: On the basis of matching the PH finding statistically we get DWI accuracy of 96.8% for the assessment of liver lesions. The average numerical value of ADC in benign hepatic lesions (FNH, Hemangiomas) in our study amounted to 1.88 (1.326 to 2.48) x10(3) mm(2) /s, while the value of malignant liver lesions (HCC, CCC, CRCLM) were significantly lower and amounted to 1.15 (1.024 to 1.343) x10(-3) mm(2) /s (Figure 2). Differences between the mean ADC of benign and malignant lesions showed a statistically significant difference with p <0.0005. In our research, we get cut-off for the ADC value of 1,341x10(-3) mm(2) /s, which proved to be the optimal parameter for differentiation between benign and malignant lesions. CONCLUSION: Measuring ADC values with DWI as an additional MRI tool can help in oncological practice by distinguishing normal liver parenchyma from focal lesions, and in differentiating benign from malignant liver lesions, particularly in cases where administration of contrast is not possible.
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spelling pubmed-50379772016-10-05 DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion Jahic, Elma Sofic, Amela Selimovic, Azra Husic Acta Inform Med Original Paper MATERIAL AND METHODS: The study was of prospective-retrospective character. It was carried out at the AKH in Vienna (Austria), where 100 patients with focal liver lesions were included in the study. All patients underwent the routine MR sequences on appliances 1,5 and 3T (Siemens, Germany): T1, T2, HASTE, VIBE, and a DWI with three b values (b 50, b 300 b 600 s / mm(2)) and ADC map with ROI (regions of interest). The numerical value of ADC map was calculated, where n = 100 liver lesions, by two independent radiologists. RESULTS: On the basis of matching the PH finding statistically we get DWI accuracy of 96.8% for the assessment of liver lesions. The average numerical value of ADC in benign hepatic lesions (FNH, Hemangiomas) in our study amounted to 1.88 (1.326 to 2.48) x10(3) mm(2) /s, while the value of malignant liver lesions (HCC, CCC, CRCLM) were significantly lower and amounted to 1.15 (1.024 to 1.343) x10(-3) mm(2) /s (Figure 2). Differences between the mean ADC of benign and malignant lesions showed a statistically significant difference with p <0.0005. In our research, we get cut-off for the ADC value of 1,341x10(-3) mm(2) /s, which proved to be the optimal parameter for differentiation between benign and malignant lesions. CONCLUSION: Measuring ADC values with DWI as an additional MRI tool can help in oncological practice by distinguishing normal liver parenchyma from focal lesions, and in differentiating benign from malignant liver lesions, particularly in cases where administration of contrast is not possible. AVICENA, d.o.o., Sarajevo 2016-07-16 2016-08 /pmc/articles/PMC5037977/ /pubmed/27708485 http://dx.doi.org/10.5455/aim.2016.24.244-247 Text en Copyright: © 2016 Elma Jahic, Amela Sofic, and Azra Husic Selimovic http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Jahic, Elma
Sofic, Amela
Selimovic, Azra Husic
DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion
title DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion
title_full DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion
title_fullStr DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion
title_full_unstemmed DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion
title_short DWI/ADC in Differentiation of Benign from Malignant Focal Liver Lesion
title_sort dwi/adc in differentiation of benign from malignant focal liver lesion
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037977/
https://www.ncbi.nlm.nih.gov/pubmed/27708485
http://dx.doi.org/10.5455/aim.2016.24.244-247
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