AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol

The Hippo pathway controls organ growth and is implicated in cancer development. Whether and how Hippo pathway activity is limited to sustain or initiate cell growth when needed is not understood. The members of the AJUBA family of LIM proteins are negative regulators of the Hippo pathway. In mammal...

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Detalles Bibliográficos
Autores principales: Jagannathan, Radhika, Schimizzi, Gregory V., Zhang, Kun, Loza, Andrew J., Yabuta, Norikazu, Nojima, Hitoshi, Longmore, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038147/
https://www.ncbi.nlm.nih.gov/pubmed/27457617
http://dx.doi.org/10.1128/MCB.00136-16

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