Cargando…

Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species

CD101 is a novel echinocandin with a long half-life undergoing clinical development for treatment of candidemia/invasive candidiasis and vulvovaginal candidiasis. The potential for and mechanisms underlying the development of resistance to CD101 in Candida species were investigated by using spontane...

Descripción completa

Detalles Bibliográficos
Autores principales:	Locke, Jeffrey B., Almaguer, Amanda L., Zuill, Douglas E., Bartizal, Ken
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038289/ https://www.ncbi.nlm.nih.gov/pubmed/27480852 http://dx.doi.org/10.1128/AAC.00620-16

Ejemplares similares

Echinocandin Resistance in Candida Species Isolates from Liver Transplant Recipients
por: Prigent, Gwénolé, et al.
Publicado: (2017)

Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance
por: Kordalewska, Milena, et al.
Publicado: (2023)

The Gastrointestinal Tract Is a Major Source of Echinocandin Drug Resistance in a Murine Model of Candida glabrata Colonization and Systemic Dissemination
por: Healey, Kelley R., et al.
Publicado: (2017)

Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species
por: Locke, Jeffrey B., et al.
Publicado: (2018)

CD101: a novel long‐acting echinocandin
por: Zhao, Yanan, et al.
Publicado: (2016)

In vitro activity of the novel echinocandin CD101 at pH 7 and 4 against Candida spp. isolates from patients with vulvovaginal candidiasis
por: Boikov, Dina A., et al.
Publicado: (2017)

Emergence of Echinocandin Resistance Due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis
por: Jiménez-Ortigosa, Cristina, et al.
Publicado: (2017)

Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species
por: Kapoor, Mili, et al.
Publicado: (2019)

A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate
por: Cavalheiro, Mafalda, et al.
Publicado: (2018)

Pyrogallol and Fluconazole Interact Synergistically In Vitro against Candida glabrata through an Efflux-Associated Mechanism
por: Yao, Dongting, et al.
Publicado: (2021)

In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis
por: McNeil, Matthew B., et al.
Publicado: (2017)

Rapid Evolution of Multidrug Resistance in a Candida lusitaniae Infection during Micafungin Monotherapy
por: Scott, Nancy E., et al.
Publicado: (2023)

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions
por: Warrilow, Andrew G., et al.
Publicado: (2019)

Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability
por: Pais, Pedro, et al.
Publicado: (2020)

Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility
por: Liston, Sean D., et al.
Publicado: (2020)

Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition
por: Niimi, Masakazu, et al.
Publicado: (2022)

CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms
por: Miron-Ocampo, Aracely, et al.
Publicado: (2023)

Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones In Vitro
por: Kim, Hyun, et al.
Publicado: (2022)

Essential Role for the Phosphatidylinositol 3,5-Bisphosphate Synthesis Complex in Caspofungin Tolerance and Virulence in Candida glabrata
por: Choudhary, Deepak Kumar, et al.
Publicado: (2019)

Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility
por: Healey, Kelley R., et al.
Publicado: (2018)

ERG11 Gene Mutations and MDR1 Upregulation Confer Pan-Azole Resistance in Candida tropicalis Causing Disseminated Candidiasis in an Acute Lymphoblastic Leukemia Patient on Posaconazole Prophylaxis
por: You, Liangshun, et al.
Publicado: (2017)

Preclinical Evaluation of the Stability, Safety, and Efficacy of CD101, a Novel Echinocandin
por: Ong, Voon, et al.
Publicado: (2016)

Comprehensive Genome Analysis of Carbapenem-Resistant Strains of Raoultella Species, an Emerging Multidrug-Resistant Bacterium in Hospitals
por: Yu, Xiao, et al.
Publicado: (2019)

Low Level of Antifungal Resistance in Iranian Isolates of Candida glabrata Recovered from Blood Samples in a Multicenter Study from 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of PDR1
por: Arastehfar, Amir, et al.
Publicado: (2019)

Omadacycline Efficacy against Enterococcus faecalis Isolated in China: In Vitro Activity, Heteroresistance, and Resistance Mechanisms
por: Lin, Zhiwei, et al.
Publicado: (2020)

Exploring Cluster-Dependent Antibacterial Activities and Resistance Pathways of NOSO-502 and Colistin against Enterobacter cloacae Complex Species
por: Pantel, Lucile, et al.
Publicado: (2022)

Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei
por: Huang, Yonglu, et al.
Publicado: (2023)

The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis
por: Hürlimann, Lea M., et al.
Publicado: (2016)

Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model
por: VanScoy, Brian D., et al.
Publicado: (2020)

Clinical Relevance of Topical Antibiotic Use in Coselecting for Multidrug-Resistant Staphylococcus aureus: Insights from In Vitro and Ex Vivo Models
por: Nong, Yi, et al.
Publicado: (2021)

Identification and Characterization of a Novel Major Facilitator Superfamily Efflux Pump, SA09310, Mediating Tetracycline Resistance in Staphylococcus aureus
por: Li, Daiyu, et al.
Publicado: (2023)

Characterization of SCCmec Instability in Methicillin-Resistant Staphylococcus aureus Affecting Adjacent Chromosomal Regions, Including the Gene for Staphylococcal Protein A (spa)
por: Scharn, C. R., et al.
Publicado: (2022)

Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri
por: Lebreton, Francois, et al.
Publicado: (2021)

Characterization of Pseudomonas aeruginosa resistance to ceftolozane-tazobactam due to ampC and/or ampD mutations observed during treatment using semi-mechanistic PKPD modeling
por: Deroche, Luc, et al.
Publicado: (2023)

In Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to Vancomycin
por: Singh, Madhuri, et al.
Publicado: (2017)

A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro
por: Patel, Nipul, et al.
Publicado: (2017)

β-Lactamase Characterization of Gram-Negative Pathogens Recovered from Patients Enrolled in the Phase 2 Trials for Ceftazidime-Avibactam: Clinical Efficacies Analyzed against Subsets of Molecularly Characterized Isolates
por: Mendes, Rodrigo E., et al.
Publicado: (2016)

In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales
por: Lomovskaya, Olga, et al.
Publicado: (2023)

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex
por: Talbot, Jessica J., et al.
Publicado: (2019)

In Vitro Activity of a Novel Glycopolymer against Biofilms of Burkholderia cepacia Complex Cystic Fibrosis Clinical Isolates
por: Narayanaswamy, Vidya P., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5j1m0r1t8etl7i6ioll6es0ggo