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Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men

Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV...

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Autores principales: Leeyaphan, Charussri, Ong, Jason J., Chow, Eric P.F., Kong, Fabian Y.S., Hocking, Jane S., Bissessor, Melanie, Fairley, Christopher K., Chen, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038401/
https://www.ncbi.nlm.nih.gov/pubmed/27513890
http://dx.doi.org/10.3201/eid2210.160986
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author Leeyaphan, Charussri
Ong, Jason J.
Chow, Eric P.F.
Kong, Fabian Y.S.
Hocking, Jane S.
Bissessor, Melanie
Fairley, Christopher K.
Chen, Marcus
author_facet Leeyaphan, Charussri
Ong, Jason J.
Chow, Eric P.F.
Kong, Fabian Y.S.
Hocking, Jane S.
Bissessor, Melanie
Fairley, Christopher K.
Chen, Marcus
author_sort Leeyaphan, Charussri
collection PubMed
description Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I(2) = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM.
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spelling pubmed-50384012016-10-12 Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men Leeyaphan, Charussri Ong, Jason J. Chow, Eric P.F. Kong, Fabian Y.S. Hocking, Jane S. Bissessor, Melanie Fairley, Christopher K. Chen, Marcus Emerg Infect Dis Research Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I(2) = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM. Centers for Disease Control and Prevention 2016-10 /pmc/articles/PMC5038401/ /pubmed/27513890 http://dx.doi.org/10.3201/eid2210.160986 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Leeyaphan, Charussri
Ong, Jason J.
Chow, Eric P.F.
Kong, Fabian Y.S.
Hocking, Jane S.
Bissessor, Melanie
Fairley, Christopher K.
Chen, Marcus
Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
title Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
title_full Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
title_fullStr Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
title_full_unstemmed Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
title_short Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
title_sort systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038401/
https://www.ncbi.nlm.nih.gov/pubmed/27513890
http://dx.doi.org/10.3201/eid2210.160986
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