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Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men
Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038401/ https://www.ncbi.nlm.nih.gov/pubmed/27513890 http://dx.doi.org/10.3201/eid2210.160986 |
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author | Leeyaphan, Charussri Ong, Jason J. Chow, Eric P.F. Kong, Fabian Y.S. Hocking, Jane S. Bissessor, Melanie Fairley, Christopher K. Chen, Marcus |
author_facet | Leeyaphan, Charussri Ong, Jason J. Chow, Eric P.F. Kong, Fabian Y.S. Hocking, Jane S. Bissessor, Melanie Fairley, Christopher K. Chen, Marcus |
author_sort | Leeyaphan, Charussri |
collection | PubMed |
description | Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I(2) = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM. |
format | Online Article Text |
id | pubmed-5038401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-50384012016-10-12 Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men Leeyaphan, Charussri Ong, Jason J. Chow, Eric P.F. Kong, Fabian Y.S. Hocking, Jane S. Bissessor, Melanie Fairley, Christopher K. Chen, Marcus Emerg Infect Dis Research Rectal lymphogranuloma venereum (LGV) has reemerged as a sexually transmitted infection among men who have sex with men (MSM), particularly those who are HIV-positive. We undertook a systematic review and meta-analysis to determine the efficacy of doxycycline (100 mg 2×/d for 21 days) for rectal LGV in MSM. Nine studies were included: 4 prospective, 4 retrospective, and 1 combined retrospective and prospective. In total, 282 MSM with rectal LGV were included in the studies. All studies reported using nucleic acid amplification tests to assess microbial cure. Most patients (>80%) had symptomatic rectal infection. The fixed-effects pooled efficacy for doxycycline was 98.5% (95% CI 96.3%–100%, I(2) = 0%; p = 0.993). Doxycycline at 100 mg twice daily for 21 days demonstrated a high microbial cure rate. These data support doxycycline at this dosage and duration as first-line therapy for rectal LGV in MSM. Centers for Disease Control and Prevention 2016-10 /pmc/articles/PMC5038401/ /pubmed/27513890 http://dx.doi.org/10.3201/eid2210.160986 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Leeyaphan, Charussri Ong, Jason J. Chow, Eric P.F. Kong, Fabian Y.S. Hocking, Jane S. Bissessor, Melanie Fairley, Christopher K. Chen, Marcus Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
title | Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
title_full | Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
title_fullStr | Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
title_full_unstemmed | Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
title_short | Systematic Review and Meta-Analysis of Doxycycline Efficacy for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men |
title_sort | systematic review and meta-analysis of doxycycline efficacy for rectal lymphogranuloma venereum in men who have sex with men |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038401/ https://www.ncbi.nlm.nih.gov/pubmed/27513890 http://dx.doi.org/10.3201/eid2210.160986 |
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