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Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report

In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pne...

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Autores principales: Kantarcioglu, Bulent, Bekoz, Huseyin Saffet, Olgun, Fatih Erkam, Cakal, Beytullah, Arkan, Burak, Turkoglu, Halil, Mert, Ali, Sargin, Deniz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038443/
https://www.ncbi.nlm.nih.gov/pubmed/27699025
http://dx.doi.org/10.3892/mco.2016.995
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author Kantarcioglu, Bulent
Bekoz, Huseyin Saffet
Olgun, Fatih Erkam
Cakal, Beytullah
Arkan, Burak
Turkoglu, Halil
Mert, Ali
Sargin, Deniz
author_facet Kantarcioglu, Bulent
Bekoz, Huseyin Saffet
Olgun, Fatih Erkam
Cakal, Beytullah
Arkan, Burak
Turkoglu, Halil
Mert, Ali
Sargin, Deniz
author_sort Kantarcioglu, Bulent
collection PubMed
description In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post-transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure. We herein report the case of a blast-phase CML patient with a highly resistant, CRKP-associated tricuspid valve endocarditis, who was treated with a combination of systemic antimicrobial therapy and surgical valve repair, and subsequently underwent a successful allo-SCT.
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spelling pubmed-50384432016-10-03 Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report Kantarcioglu, Bulent Bekoz, Huseyin Saffet Olgun, Fatih Erkam Cakal, Beytullah Arkan, Burak Turkoglu, Halil Mert, Ali Sargin, Deniz Mol Clin Oncol Articles In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post-transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure. We herein report the case of a blast-phase CML patient with a highly resistant, CRKP-associated tricuspid valve endocarditis, who was treated with a combination of systemic antimicrobial therapy and surgical valve repair, and subsequently underwent a successful allo-SCT. D.A. Spandidos 2016-10 2016-08-17 /pmc/articles/PMC5038443/ /pubmed/27699025 http://dx.doi.org/10.3892/mco.2016.995 Text en Copyright: © Kantarcioglu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Kantarcioglu, Bulent
Bekoz, Huseyin Saffet
Olgun, Fatih Erkam
Cakal, Beytullah
Arkan, Burak
Turkoglu, Halil
Mert, Ali
Sargin, Deniz
Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report
title Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report
title_full Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report
title_fullStr Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report
title_full_unstemmed Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report
title_short Allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant Klebsiella pneumoniae tricuspid valve endocarditis: A case report
title_sort allogeneic stem cell transplantation in a blast-phase chronic myeloid leukemia patient with carbapenem-resistant klebsiella pneumoniae tricuspid valve endocarditis: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038443/
https://www.ncbi.nlm.nih.gov/pubmed/27699025
http://dx.doi.org/10.3892/mco.2016.995
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