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Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients

Despite the fact that testicular germ cell tumors (TGCTs) are one of the most chemosensitive solid tumors, a small proportion of patients fail to be cured following cisplatin-based first line chemotherapy. Upregulation of carbonic anhydrase IX (CA IX) in various solid tumors is associated with poor...

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Autores principales: Kalavska, Katarina, Chovanec, Michal, Zatovicova, Miriam, Takacova, Martina, Gronesova, Paulina, Svetlovska, Daniela, Baratova, Magdalena, Miskovska, Vera, Obertova, Jana, Palacka, Patrik, Rajec, Jan, Sycova-Mila, Zuzana, Cierna, Zuzana, Kajo, Karol, Spanik, Stanislav, Babal, Pavel, Mardiak, Jozef, Pastorekova, Silvia, Mego, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038507/
https://www.ncbi.nlm.nih.gov/pubmed/27698832
http://dx.doi.org/10.3892/ol.2016.5010
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author Kalavska, Katarina
Chovanec, Michal
Zatovicova, Miriam
Takacova, Martina
Gronesova, Paulina
Svetlovska, Daniela
Baratova, Magdalena
Miskovska, Vera
Obertova, Jana
Palacka, Patrik
Rajec, Jan
Sycova-Mila, Zuzana
Cierna, Zuzana
Kajo, Karol
Spanik, Stanislav
Babal, Pavel
Mardiak, Jozef
Pastorekova, Silvia
Mego, Michal
author_facet Kalavska, Katarina
Chovanec, Michal
Zatovicova, Miriam
Takacova, Martina
Gronesova, Paulina
Svetlovska, Daniela
Baratova, Magdalena
Miskovska, Vera
Obertova, Jana
Palacka, Patrik
Rajec, Jan
Sycova-Mila, Zuzana
Cierna, Zuzana
Kajo, Karol
Spanik, Stanislav
Babal, Pavel
Mardiak, Jozef
Pastorekova, Silvia
Mego, Michal
author_sort Kalavska, Katarina
collection PubMed
description Despite the fact that testicular germ cell tumors (TGCTs) are one of the most chemosensitive solid tumors, a small proportion of patients fail to be cured following cisplatin-based first line chemotherapy. Upregulation of carbonic anhydrase IX (CA IX) in various solid tumors is associated with poor outcome. The current prospective study investigated the prognostic value of serum CA IX level in TGCTs. In total, 83 patients (16 non-metastatic following orchiectomy with no evidence of disease, 57 metastatic chemotherapy-naïve and 10 metastatic relapsed chemotherapy-pretreated) starting adjuvant and/or new line of chemotherapy and 35 healthy controls were enrolled in the study. Serum CA IX values were determined using an enzyme-linked immunosorbent assay, and intratumoral CA IX was analyzed by immunohistochemistry. Metastatic chemotherapy-naïve patients had significantly higher mean CA IX serum levels than healthy controls (490.6 vs. 249.6 pg/ml, P=0.005), while there was no difference in serum CA IX levels in non-metastatic or relapsed TGCT patients compared with healthy controls. There was no significant difference in the mean serum CA IX levels between different groups of patients and between the first and second cycle of chemotherapy, nor association with patients/tumor characteristics. Serum CA IX was not prognostic for progression-free survival [hazard ratio (HR)=0.81, P=0.730] or overall survival (HR=0.64, P=0.480). However, there was a significant association between intratumoral CA IX expression and serum CA IX concentration (rho=0.51, P=0.040). These results suggest that serum CA IX level correlates with tumor CA IX expression in TGCT patients, but fails to exhibit either a prognostic value or an association with patients/tumor characteristics.
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spelling pubmed-50385072016-10-03 Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients Kalavska, Katarina Chovanec, Michal Zatovicova, Miriam Takacova, Martina Gronesova, Paulina Svetlovska, Daniela Baratova, Magdalena Miskovska, Vera Obertova, Jana Palacka, Patrik Rajec, Jan Sycova-Mila, Zuzana Cierna, Zuzana Kajo, Karol Spanik, Stanislav Babal, Pavel Mardiak, Jozef Pastorekova, Silvia Mego, Michal Oncol Lett Articles Despite the fact that testicular germ cell tumors (TGCTs) are one of the most chemosensitive solid tumors, a small proportion of patients fail to be cured following cisplatin-based first line chemotherapy. Upregulation of carbonic anhydrase IX (CA IX) in various solid tumors is associated with poor outcome. The current prospective study investigated the prognostic value of serum CA IX level in TGCTs. In total, 83 patients (16 non-metastatic following orchiectomy with no evidence of disease, 57 metastatic chemotherapy-naïve and 10 metastatic relapsed chemotherapy-pretreated) starting adjuvant and/or new line of chemotherapy and 35 healthy controls were enrolled in the study. Serum CA IX values were determined using an enzyme-linked immunosorbent assay, and intratumoral CA IX was analyzed by immunohistochemistry. Metastatic chemotherapy-naïve patients had significantly higher mean CA IX serum levels than healthy controls (490.6 vs. 249.6 pg/ml, P=0.005), while there was no difference in serum CA IX levels in non-metastatic or relapsed TGCT patients compared with healthy controls. There was no significant difference in the mean serum CA IX levels between different groups of patients and between the first and second cycle of chemotherapy, nor association with patients/tumor characteristics. Serum CA IX was not prognostic for progression-free survival [hazard ratio (HR)=0.81, P=0.730] or overall survival (HR=0.64, P=0.480). However, there was a significant association between intratumoral CA IX expression and serum CA IX concentration (rho=0.51, P=0.040). These results suggest that serum CA IX level correlates with tumor CA IX expression in TGCT patients, but fails to exhibit either a prognostic value or an association with patients/tumor characteristics. D.A. Spandidos 2016-10 2016-08-16 /pmc/articles/PMC5038507/ /pubmed/27698832 http://dx.doi.org/10.3892/ol.2016.5010 Text en Copyright: © Kalavska et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Kalavska, Katarina
Chovanec, Michal
Zatovicova, Miriam
Takacova, Martina
Gronesova, Paulina
Svetlovska, Daniela
Baratova, Magdalena
Miskovska, Vera
Obertova, Jana
Palacka, Patrik
Rajec, Jan
Sycova-Mila, Zuzana
Cierna, Zuzana
Kajo, Karol
Spanik, Stanislav
Babal, Pavel
Mardiak, Jozef
Pastorekova, Silvia
Mego, Michal
Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
title Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
title_full Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
title_fullStr Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
title_full_unstemmed Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
title_short Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
title_sort prognostic value of serum carbonic anhydrase ix in testicular germ cell tumor patients
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038507/
https://www.ncbi.nlm.nih.gov/pubmed/27698832
http://dx.doi.org/10.3892/ol.2016.5010
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