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A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism

Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human meta...

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Detalles Bibliográficos
Autores principales: Vasiliadou, Rafaela, Nasr Esfahani, Mohammad Mehdi, Brown, Nathan J., Welham, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038696/
https://www.ncbi.nlm.nih.gov/pubmed/27598162
http://dx.doi.org/10.3390/s16091418
Descripción
Sumario:Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry (EC) with mass spectrometry (MS) has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode (SPE) for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods.