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Hypersplenism: History and current status
Hypersplenism is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells. This review summarizes the history of hypersplenism, discuss its classification and pathogenesis, and examines its diagnosis and treatment options. We performed a compr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038876/ https://www.ncbi.nlm.nih.gov/pubmed/27703501 http://dx.doi.org/10.3892/etm.2016.3683 |
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author | Lv, Yunfu Lau, Wan Yee Li, Yejuan Deng, Jie Han, Xiaoyu Gong, Xiaoguang Liu, Ning Wu, Hongfei |
author_facet | Lv, Yunfu Lau, Wan Yee Li, Yejuan Deng, Jie Han, Xiaoyu Gong, Xiaoguang Liu, Ning Wu, Hongfei |
author_sort | Lv, Yunfu |
collection | PubMed |
description | Hypersplenism is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells. This review summarizes the history of hypersplenism, discuss its classification and pathogenesis, and examines its diagnosis and treatment options. We performed a comprehensive literature search using PubMed, Web of Knowledge and the China National Knowledge Infrastructure (CNKI) database, reviewed hypersplenism-related articles and summarized the major findings. According to its etiological causes, hypersplenism is characterized by splenomegaly and peripheral cytopenias. It can be classified into three categories: i) primary hypersplenism; ii) secondary hypersplenism; and iii) occult hypersplenism. A number of mechanisms causing hypersplenism have been identified, and mainly involve retention in the spleen, phagocytosis, and autoimmunity. Treatment options for hypersplenism include etiological treatment, non-surgical treatment, total splenectomy and liver transplantation. In any case, treatment should be individualized for each patient. |
format | Online Article Text |
id | pubmed-5038876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-50388762016-10-04 Hypersplenism: History and current status Lv, Yunfu Lau, Wan Yee Li, Yejuan Deng, Jie Han, Xiaoyu Gong, Xiaoguang Liu, Ning Wu, Hongfei Exp Ther Med Review Hypersplenism is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells. This review summarizes the history of hypersplenism, discuss its classification and pathogenesis, and examines its diagnosis and treatment options. We performed a comprehensive literature search using PubMed, Web of Knowledge and the China National Knowledge Infrastructure (CNKI) database, reviewed hypersplenism-related articles and summarized the major findings. According to its etiological causes, hypersplenism is characterized by splenomegaly and peripheral cytopenias. It can be classified into three categories: i) primary hypersplenism; ii) secondary hypersplenism; and iii) occult hypersplenism. A number of mechanisms causing hypersplenism have been identified, and mainly involve retention in the spleen, phagocytosis, and autoimmunity. Treatment options for hypersplenism include etiological treatment, non-surgical treatment, total splenectomy and liver transplantation. In any case, treatment should be individualized for each patient. D.A. Spandidos 2016-10 2016-09-07 /pmc/articles/PMC5038876/ /pubmed/27703501 http://dx.doi.org/10.3892/etm.2016.3683 Text en Copyright: © Lv et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Lv, Yunfu Lau, Wan Yee Li, Yejuan Deng, Jie Han, Xiaoyu Gong, Xiaoguang Liu, Ning Wu, Hongfei Hypersplenism: History and current status |
title | Hypersplenism: History and current status |
title_full | Hypersplenism: History and current status |
title_fullStr | Hypersplenism: History and current status |
title_full_unstemmed | Hypersplenism: History and current status |
title_short | Hypersplenism: History and current status |
title_sort | hypersplenism: history and current status |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038876/ https://www.ncbi.nlm.nih.gov/pubmed/27703501 http://dx.doi.org/10.3892/etm.2016.3683 |
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