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A Positive Selection for Nucleoside Kinases in E. coli

Engineering heterologous nucleoside kinases inside E. coli is a difficult process due to the integral role nucleosides play in cell division and transcription. Nucleoside analogs are used in many kinase screens that depend on cellular metabolization of the analogs. However, metabolic activation of t...

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Detalles Bibliográficos
Autores principales:	Shelat, Nirav Y., Parhi, Sidhartha, Ostermeier, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038940/ https://www.ncbi.nlm.nih.gov/pubmed/27677184 http://dx.doi.org/10.1371/journal.pone.0162921

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