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Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases

Eukaryotes require 3 DNA polymerases for normal replisome operations, DNA polymerases (Pol) α, delta and epsilon. Recent biochemical and structural studies support the asymmetric use of these polymerases on the leading and lagging strands. Pol epsilon interacts with the 11-subunit CMG helicase, form...

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Detalles Bibliográficos
Autores principales:	Yurieva, Olga, O'Donnell, Mike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Extra View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039002/ https://www.ncbi.nlm.nih.gov/pubmed/27416113 http://dx.doi.org/10.1080/19491034.2016.1205774

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