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Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage

Holliday junctions (HJs) are key DNA intermediates in homologous recombination. They link homologous DNA strands and have to be faithfully removed for proper DNA segregation and genome integrity. Here, we present the crystal structure of human HJ resolvase GEN1 complexed with DNA at 3.0 Å resolution...

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Detalles Bibliográficos
Autores principales:	Lee, Shun-Hsiao, Princz, Lissa Nicola, Klügel, Maren Felizitas, Habermann, Bianca, Pfander, Boris, Biertümpfel, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039027/ https://www.ncbi.nlm.nih.gov/pubmed/26682650 http://dx.doi.org/10.7554/eLife.12256

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