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Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses’ silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by...

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Detalles Bibliográficos
Autores principales:	Amabile, Angelo, Migliara, Alessandro, Capasso, Paola, Biffi, Mauro, Cittaro, Davide, Naldini, Luigi, Lombardo, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039111/ https://www.ncbi.nlm.nih.gov/pubmed/27662090 http://dx.doi.org/10.1016/j.cell.2016.09.006

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