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A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers

The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brai...

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Autores principales: Wu, Xia, Li, Qing, Yu, Xinyu, Chen, Kewei, Fleisher, Adam S., Guo, Xiaojuan, Zhang, Jiacai, Reiman, Eric M., Yao, Li, Li, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039208/
https://www.ncbi.nlm.nih.gov/pubmed/27733827
http://dx.doi.org/10.3389/fnagi.2016.00231
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author Wu, Xia
Li, Qing
Yu, Xinyu
Chen, Kewei
Fleisher, Adam S.
Guo, Xiaojuan
Zhang, Jiacai
Reiman, Eric M.
Yao, Li
Li, Rui
author_facet Wu, Xia
Li, Qing
Yu, Xinyu
Chen, Kewei
Fleisher, Adam S.
Guo, Xiaojuan
Zhang, Jiacai
Reiman, Eric M.
Yao, Li
Li, Rui
author_sort Wu, Xia
collection PubMed
description The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimer’s disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology.
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spelling pubmed-50392082016-10-12 A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers Wu, Xia Li, Qing Yu, Xinyu Chen, Kewei Fleisher, Adam S. Guo, Xiaojuan Zhang, Jiacai Reiman, Eric M. Yao, Li Li, Rui Front Aging Neurosci Neuroscience The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimer’s disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology. Frontiers Media S.A. 2016-09-28 /pmc/articles/PMC5039208/ /pubmed/27733827 http://dx.doi.org/10.3389/fnagi.2016.00231 Text en Copyright © 2016 Wu, Li, Yu, Chen, Fleisher, Guo, Zhang, Reiman, Yao and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wu, Xia
Li, Qing
Yu, Xinyu
Chen, Kewei
Fleisher, Adam S.
Guo, Xiaojuan
Zhang, Jiacai
Reiman, Eric M.
Yao, Li
Li, Rui
A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
title A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
title_full A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
title_fullStr A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
title_full_unstemmed A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
title_short A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
title_sort triple network connectivity study of large-scale brain systems in cognitively normal apoe4 carriers
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039208/
https://www.ncbi.nlm.nih.gov/pubmed/27733827
http://dx.doi.org/10.3389/fnagi.2016.00231
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