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Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria

Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global health problem with high incidence and low survival rates. While the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained....

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Autores principales: Perera, Manosha, Al-hebshi, Nezar Noor, Speicher, David J., Perera, Irosha, Johnson, Newell W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039235/
https://www.ncbi.nlm.nih.gov/pubmed/27677454
http://dx.doi.org/10.3402/jom.v8.32762
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author Perera, Manosha
Al-hebshi, Nezar Noor
Speicher, David J.
Perera, Irosha
Johnson, Newell W.
author_facet Perera, Manosha
Al-hebshi, Nezar Noor
Speicher, David J.
Perera, Irosha
Johnson, Newell W.
author_sort Perera, Manosha
collection PubMed
description Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global health problem with high incidence and low survival rates. While the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained. In light of evidence implicating bacteria in the aetiology of some cancer types, several epidemiological studies have been conducted in the last decade, employing methodologies ranging from traditional culture techniques to 16S rRNA metagenomics, to assess the possible role of bacteria in OSCC. While these studies have demonstrated differences in microbial composition between cancerous and healthy tissues, they have failed to agree on specific bacteria or patterns of oral microbial dysbiosis to implicate in OSCC. On the contrary, some oral taxa, particularly Porphyromonas gingivalis and Fusobacterium nucleatum, show strong oral carcinogenic potential in vitro and in animal studies. Bacteria are thought to contribute to oral carcinogenesis via inhibition of apoptosis, activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation, and production of carcinogens. This narrative review provides a critical analysis of and an update on the association between bacteria and oral carcinogenesis and the possible mechanisms underlying it.
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spelling pubmed-50392352016-11-17 Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria Perera, Manosha Al-hebshi, Nezar Noor Speicher, David J. Perera, Irosha Johnson, Newell W. J Oral Microbiol Review Article Oral cancer, primarily oral squamous cell carcinoma (OSCC), continues to be a major global health problem with high incidence and low survival rates. While the major risk factors for this malignancy, mostly lifestyle related, have been identified, around 15% of oral cancer cases remain unexplained. In light of evidence implicating bacteria in the aetiology of some cancer types, several epidemiological studies have been conducted in the last decade, employing methodologies ranging from traditional culture techniques to 16S rRNA metagenomics, to assess the possible role of bacteria in OSCC. While these studies have demonstrated differences in microbial composition between cancerous and healthy tissues, they have failed to agree on specific bacteria or patterns of oral microbial dysbiosis to implicate in OSCC. On the contrary, some oral taxa, particularly Porphyromonas gingivalis and Fusobacterium nucleatum, show strong oral carcinogenic potential in vitro and in animal studies. Bacteria are thought to contribute to oral carcinogenesis via inhibition of apoptosis, activation of cell proliferation, promotion of cellular invasion, induction of chronic inflammation, and production of carcinogens. This narrative review provides a critical analysis of and an update on the association between bacteria and oral carcinogenesis and the possible mechanisms underlying it. Co-Action Publishing 2016-09-26 /pmc/articles/PMC5039235/ /pubmed/27677454 http://dx.doi.org/10.3402/jom.v8.32762 Text en © 2016 Manosha Perera et al. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Perera, Manosha
Al-hebshi, Nezar Noor
Speicher, David J.
Perera, Irosha
Johnson, Newell W.
Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
title Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
title_full Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
title_fullStr Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
title_full_unstemmed Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
title_short Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
title_sort emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039235/
https://www.ncbi.nlm.nih.gov/pubmed/27677454
http://dx.doi.org/10.3402/jom.v8.32762
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