Cargando…

P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation

Inflammation is a common process associated with numerous vascular pathologies. We hypothesized that targeting the inflamed endothelium by coupling a peptide with high affinity for P-selectin to the surface of dexamethasone-loaded lipid nanoemulsions will highly increase their specific binding to ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simion, Viorel, Constantinescu, Cristina Ana, Stan, Daniela, Deleanu, Mariana, Tucureanu, Monica Madalina, Butoi, Elena, Manduteanu, Ileana, Simionescu, Maya, Calin, Manuela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039295/ https://www.ncbi.nlm.nih.gov/pubmed/27703301 http://dx.doi.org/10.1155/2016/1625149

Ejemplares similares

Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells
por: Constantinescu, Cristina Ana, et al.
Publicado: (2019)

Lipopolysaccharide-induced inflammation in monocytes/macrophages is blocked by liposomal delivery of G(i)-protein inhibitor
por: Tucureanu, Monica Madalina, et al.
Publicado: (2017)

Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation
por: Fuior, Elena Valeria, et al.
Publicado: (2019)

Evaluation of VCAM-1 Targeted Naringenin/Indocyanine Green-Loaded Lipid Nanoemulsions as Theranostic Nanoplatforms in Inflammation
por: Fuior, Elena Valeria, et al.
Publicado: (2020)

The expression of MMP‐1 and MMP‐9 is up‐regulated by smooth muscle cells after their cross‐talk with macrophages in high glucose conditions
por: Macarie, Razvan Daniel, et al.
Publicado: (2018)

Inflammation in atherosclerosis: a cause or a result of vascular disorders?
por: Manduteanu, Ileana, et al.
Publicado: (2012)

Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1β and IL-6
por: Macarie, Răzvan Daniel, et al.
Publicado: (2023)

Parathyroid Hormone Induces Human Valvular Endothelial Cells Dysfunction That Impacts the Osteogenic Phenotype of Valvular Interstitial Cells
por: Vadana, Mihaela, et al.
Publicado: (2022)

Chronic High Glucose Concentration Induces Inflammatory and Remodeling Changes in Valvular Endothelial Cells and Valvular Interstitial Cells in a Gelatin Methacrylate 3D Model of the Human Aortic Valve
por: Ciortan, Letitia, et al.
Publicado: (2020)

Aortic valve disease in diabetes: Molecular mechanisms and novel therapies
por: Manduteanu, Ileana, et al.
Publicado: (2021)

High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root
por: Cecoltan, Sergiu, et al.
Publicado: (2021)

Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells
por: Voicu, Geanina, et al.
Publicado: (2020)

Diabetes-induced early molecular and functional changes in aortic heart valves in a murine model of atherosclerosis
por: Tucureanu, Monica Madalina, et al.
Publicado: (2019)

Molecular mechanisms involved in high glucose‐induced valve calcification in a 3D valve model with human valvular cells
por: Vadana, Mihaela, et al.
Publicado: (2020)

VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment
por: Voicu, Geanina, et al.
Publicado: (2022)

Integrins α4β1 and αVβ3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease
por: Filippi, Alexandru, et al.
Publicado: (2020)

Antitumor Properties of a New Macrocyclic Tetranuclear Oxidovanadium(V) Complex with 3-Methoxysalicylidenvaline Ligand
por: Turtoi, Mihaela, et al.
Publicado: (2022)

VLA4-Enhanced Allogeneic Endothelial Progenitor Cell-Based Therapy Preserves the Aortic Valve Function in a Mouse Model of Dyslipidemia and Diabetes
por: Filippi, Alexandru, et al.
Publicado: (2022)

Magnetic Nanoemulsions for the Intra-Articular Delivery of Ascorbic Acid and Dexamethasone
por: Zară-Dănceanu, Camelia Mihaela, et al.
Publicado: (2023)

Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe
por: Manea, Simona-Adriana, et al.
Publicado: (2021)

Synthesis, Characterization, and In Vitro Insulin-Mimetic Activity Evaluation of Valine Schiff Base Coordination Compounds of Oxidovanadium(V)
por: Turtoi, Mihaela, et al.
Publicado: (2021)

Preparation and in vitro and in vivo Study of Asiaticoside-Loaded Nanoemulsions and Nanoemulsions-Based Gels for Transdermal Delivery
por: Li, Huimin, et al.
Publicado: (2020)

Development of Dextran-Coated Magnetic Nanoparticles Loaded with Protocatechuic Acid for Vascular Inflammation Therapy
por: Anghelache, Maria, et al.
Publicado: (2021)

Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation
por: Mihaila, Andreea C., et al.
Publicado: (2021)

Preparation and In Vivo Evaluation of Indomethacin Loaded True Nanoemulsions
por: Shakeel, Faiyaz, et al.
Publicado: (2010)

Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin
por: Jiang, Sai-Ping, et al.
Publicado: (2013)

Biocompatible Nutmeg Oil-Loaded Nanoemulsion as Phyto-Repellent
por: Mohd Narawi, Masturah, et al.
Publicado: (2020)

Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion
por: Dantas, Amanda Gabrielle Barros, et al.
Publicado: (2021)

Effect of irreversibly glycated LDL in human vascular smooth muscle cells: lipid loading, oxidative and inflammatory stress
por: Sima, Anca V, et al.
Publicado: (2010)

Long Non-Coding RNAs in Vascular Inflammation
por: Haemmig, Stefan, et al.
Publicado: (2018)

Nanoemulsion‐Loaded Capsules for Controlled Delivery of Lipophilic Active Ingredients
por: Chen, Liang‐Hsun, et al.
Publicado: (2020)

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability
por: Anuar, Nurfazreen, et al.
Publicado: (2020)

Development of Chrysin Loaded Oil-in-Water Nanoemulsion for Improving Bioaccessibility
por: Ting, Pisamai, et al.
Publicado: (2021)

Cytotoxicity and Anti-Plasmodium berghei Activity of Emodin Loaded Nanoemulsion
por: Bayat, Fatemeh, et al.
Publicado: (2022)

Alginate-pectin microparticles loaded with nanoemulsions as nanocomposites for wound healing
por: Amante, Chiara, et al.
Publicado: (2022)

Systematic Review and Meta-Analysis of the Effect of Statins on Circulating E-Selectin, L-Selectin, and P-Selectin
por: Zinellu, Angelo, et al.
Publicado: (2021)

‘Cellular dysfunction in inflammatory-related vascular disorders’ Review Series The inflammatory process: a new dimension of a 19(th) century old story
por: Simionescu, Maya
Publicado: (2009)

Epigenetic regulation of vascular NADPH oxidase expression and reactive oxygen species production by histone deacetylase-dependent mechanisms in experimental diabetes
por: Manea, Simona-Adriana, et al.
Publicado: (2018)

The Kinetics of L-selectin Tethers and the Mechanics of Selectin-mediated Rolling
por: Alon, Ronen, et al.
Publicado: (1997)

Curcumin and Quercetin-Loaded Nanoemulsions: Physicochemical Compatibility Study and Validation of a Simultaneous Quantification Method
por: Vaz, Gustavo Richter, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_uq68l1phrq9q9ei1aide5l8vsj