Cargando…

Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth

DNA methylation is a fundamental feature of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantage. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention. By focusing on interactions existing between DNMT3A and DNMT...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheray, Mathilde, Pacaud, Romain, Nadaradjane, Arulraj, Oliver, Lisa, Vallette, François M, Cartron, Pierre-François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039338/ https://www.ncbi.nlm.nih.gov/pubmed/27698935 http://dx.doi.org/10.7150/thno.9150

Ejemplares similares

Specific inhibition of one DNMT1-including complex influences tumor initiation and progression
por: Cheray, Mathilde, et al.
Publicado: (2013)

Histone H3 Phosphorylation in GBM: a New Rational to Guide the Use of Kinase Inhibitors in anti-GBM Therapy
por: Pacaud, Romain, et al.
Publicado: (2015)

Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle
por: Hervouet, Eric, et al.
Publicado: (2012)

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme
por: Cheray, Mathilde, et al.
Publicado: (2020)

The DNMT1/PCNA/UHRF1 disruption induces tumorigenesis characterized by similar genetic and epigenetic signatures
por: Pacaud, Romain, et al.
Publicado: (2014)

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker
por: Nadaradjane, Arulraj, et al.
Publicado: (2018)

Diuron exposure and Akt overexpression promote glioma formation through DNA hypomethylation
por: Briand, Joséphine, et al.
Publicado: (2019)

N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool
por: Briand, Joséphine, et al.
Publicado: (2020)

Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner
por: Duforestel, Manon, et al.
Publicado: (2019)

DNA Methylation and Apoptosis Resistance in Cancer Cells
por: Hervouet, Eric, et al.
Publicado: (2013)

Disruption of Dnmt1/PCNA/UHRF1 Interactions Promotes Tumorigenesis from Human and Mice Glial Cells
por: Hervouet, Eric, et al.
Publicado: (2010)

Adenosine Methylation Level of miR-125a-5p Promotes Anti-PD-1 Therapy Escape through the Regulation of IGSF11/VSIG3 Expression
por: Bougras-Cartron, Gwenola, et al.
Publicado: (2023)

Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma
por: Rabé, Marion, et al.
Publicado: (2020)

Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells
por: Guyon, Nina, et al.
Publicado: (2020)

ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
por: González-Rodríguez, Patricia, et al.
Publicado: (2022)

Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma
por: Gratas, Catherine, et al.
Publicado: (2014)

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells
por: Yamagami, Mari, et al.
Publicado: (2018)

Drug resistance in glioblastoma: are persisters the key to therapy?
por: Oliver, Lisa, et al.
Publicado: (2020)

The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p
por: Garnier, Delphine, et al.
Publicado: (2022)

Control of glioma cell death and differentiation by PKM2–Oct4 interaction
por: Morfouace, M, et al.
Publicado: (2014)

The DNA methyltransferase DNMT3A contributes to autophagy long-term memory
por: González-Rodríguez, Patricia, et al.
Publicado: (2020)

Proximity ligation in situ assay for monitoring the global DNA methylation in cells
por: Hervouet, Eric, et al.
Publicado: (2011)

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function
por: Rengachari, Srinivasan, et al.
Publicado: (2018)

Data supporting the roles of BAP1, STING, and IFN-β in ISGF3 activation in ccRCC
por: Langbein, Lauren E., et al.
Publicado: (2022)

Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment
por: Rabé, Marion, et al.
Publicado: (2022)

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
por: Gallenne, Tristan, et al.
Publicado: (2009)

Time-dependent recruitment of GAF, ISGF3 and IRF1 complexes shapes IFNα and IFNγ-activated transcriptional responses and explains mechanistic and functional overlap
por: Sekrecka, Agata, et al.
Publicado: (2023)

The Fish-Specific Protein Kinase (PKZ) Initiates Innate Immune Responses via IRF3- and ISGF3-Like Mediated Pathways
por: Xu, Xiaowen, et al.
Publicado: (2019)

Correlations among PPARγ, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer
por: Pazienza, Valerio, et al.
Publicado: (2012)

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
por: Platanitis, Ekaterini, et al.
Publicado: (2019)

Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection
por: Geary, Clair D., et al.
Publicado: (2018)

D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH
por: Oizel, K, et al.
Publicado: (2015)

High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells
por: Kishimoto, Kensei, et al.
Publicado: (2021)

ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients
por: Debien, Emilie, et al.
Publicado: (2011)

Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ
por: Rinaldi, Lorenzo, et al.
Publicado: (2017)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
por: Van Emburgh, Beth O., et al.
Publicado: (2011)

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1
por: Blaszczyk, Katarzyna, et al.
Publicado: (2015)

Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
por: Stepper, Peter, et al.
Publicado: (2017)

TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis
por: Lalier, Lisenn, et al.
Publicado: (2021)

Time-Qualified Patterns of Variation of PPARγ, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines
por: Pazienza, Valerio, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_5h6v43idnhia1hsklgccf1ba34