Low Proteolytic Clipping of Histone H3 in Cervical Cancer

Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not...

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Detalles Bibliográficos
Autores principales: Sandoval-Basilio, Jorge, Serafín-Higuera, Nicolás, Reyes-Hernandez, Octavio D., Serafín-Higuera, Idanya, Leija-Montoya, Gabriela, Blanco-Morales, Magali, Sierra-Martínez, Monica, Ramos-Mondragon, Roberto, García, Silvia, López-Hernández, Luz Berenice, Yocupicio-Monroy, Martha, Alcaraz-Estrada, Sofia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039369/
https://www.ncbi.nlm.nih.gov/pubmed/27698925
http://dx.doi.org/10.7150/jca.15605
Descripción
Sumario:Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not been reported. Using HeLa cells as a model of CC and human samples from patients with CC, we identify that the H3 cleavage was lower in CC compared with control tissue. Additionally, the histone H3 clipping was performed by serine and aspartyl proteases in HeLa cells. These results suggest that histone H3 clipping operates as part of post-translational modification system in CC.

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