Low Proteolytic Clipping of Histone H3 in Cervical Cancer

Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not...

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Autores principales: Sandoval-Basilio, Jorge, Serafín-Higuera, Nicolás, Reyes-Hernandez, Octavio D., Serafín-Higuera, Idanya, Leija-Montoya, Gabriela, Blanco-Morales, Magali, Sierra-Martínez, Monica, Ramos-Mondragon, Roberto, García, Silvia, López-Hernández, Luz Berenice, Yocupicio-Monroy, Martha, Alcaraz-Estrada, Sofia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Short Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039369/
https://www.ncbi.nlm.nih.gov/pubmed/27698925
http://dx.doi.org/10.7150/jca.15605
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author Sandoval-Basilio, Jorge
Serafín-Higuera, Nicolás
Reyes-Hernandez, Octavio D.
Serafín-Higuera, Idanya
Leija-Montoya, Gabriela
Blanco-Morales, Magali
Sierra-Martínez, Monica
Ramos-Mondragon, Roberto
García, Silvia
López-Hernández, Luz Berenice
Yocupicio-Monroy, Martha
Alcaraz-Estrada, Sofia L.
author_facet Sandoval-Basilio, Jorge
Serafín-Higuera, Nicolás
Reyes-Hernandez, Octavio D.
Serafín-Higuera, Idanya
Leija-Montoya, Gabriela
Blanco-Morales, Magali
Sierra-Martínez, Monica
Ramos-Mondragon, Roberto
García, Silvia
López-Hernández, Luz Berenice
Yocupicio-Monroy, Martha
Alcaraz-Estrada, Sofia L.
author_sort Sandoval-Basilio, Jorge
collection PubMed
description Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not been reported. Using HeLa cells as a model of CC and human samples from patients with CC, we identify that the H3 cleavage was lower in CC compared with control tissue. Additionally, the histone H3 clipping was performed by serine and aspartyl proteases in HeLa cells. These results suggest that histone H3 clipping operates as part of post-translational modification system in CC.
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spelling pubmed-50393692016-10-03 Low Proteolytic Clipping of Histone H3 in Cervical Cancer Sandoval-Basilio, Jorge Serafín-Higuera, Nicolás Reyes-Hernandez, Octavio D. Serafín-Higuera, Idanya Leija-Montoya, Gabriela Blanco-Morales, Magali Sierra-Martínez, Monica Ramos-Mondragon, Roberto García, Silvia López-Hernández, Luz Berenice Yocupicio-Monroy, Martha Alcaraz-Estrada, Sofia L. J Cancer Short Research Communication Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes. Recently, a potential mechanism, which regulates gene expression at transcriptional levels is the proteolytic clipping of histone H3. However, until now this process in CC has not been reported. Using HeLa cells as a model of CC and human samples from patients with CC, we identify that the H3 cleavage was lower in CC compared with control tissue. Additionally, the histone H3 clipping was performed by serine and aspartyl proteases in HeLa cells. These results suggest that histone H3 clipping operates as part of post-translational modification system in CC. Ivyspring International Publisher 2016-08-17 /pmc/articles/PMC5039369/ /pubmed/27698925 http://dx.doi.org/10.7150/jca.15605 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Short Research Communication
Sandoval-Basilio, Jorge
Serafín-Higuera, Nicolás
Reyes-Hernandez, Octavio D.
Serafín-Higuera, Idanya
Leija-Montoya, Gabriela
Blanco-Morales, Magali
Sierra-Martínez, Monica
Ramos-Mondragon, Roberto
García, Silvia
López-Hernández, Luz Berenice
Yocupicio-Monroy, Martha
Alcaraz-Estrada, Sofia L.
Low Proteolytic Clipping of Histone H3 in Cervical Cancer
title Low Proteolytic Clipping of Histone H3 in Cervical Cancer
title_full Low Proteolytic Clipping of Histone H3 in Cervical Cancer
title_fullStr Low Proteolytic Clipping of Histone H3 in Cervical Cancer
title_full_unstemmed Low Proteolytic Clipping of Histone H3 in Cervical Cancer
title_short Low Proteolytic Clipping of Histone H3 in Cervical Cancer
title_sort low proteolytic clipping of histone h3 in cervical cancer
topic Short Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039369/
https://www.ncbi.nlm.nih.gov/pubmed/27698925
http://dx.doi.org/10.7150/jca.15605
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