Cargando…
Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities. Here, we show that different phenothiazine derivatives and pyronine G inhibited the activ...
Autores principales: | Wu, Shiying, Mao, Guanzhong, Kirsebom, Leif A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039424/ https://www.ncbi.nlm.nih.gov/pubmed/27618117 http://dx.doi.org/10.3390/biom6030038 |
Ejemplares similares
-
Cleavage mediated by the P15 domain of bacterial RNase P RNA
por: Kikovska, Ema, et al.
Publicado: (2012) -
Importance of residue 248 in Escherichia coli RNase P RNA mediated cleavage
por: Mao, Guanzhong, et al.
Publicado: (2023) -
Critical domain interactions for type A RNase P RNA catalysis with and without the specificity domain
por: Mao, Guanzhong, et al.
Publicado: (2018) -
Substrate discrimination in RNase P RNA-mediated cleavage: importance of the structural environment of the RNase P cleavage site
por: Kikovska, Ema, et al.
Publicado: (2005) -
Transition-state stabilization in Escherichia coli ribonuclease P RNA-mediated cleavage of model substrates
por: Wu, Shiying, et al.
Publicado: (2014)