The Use of Deep Brain Stimulation in Tourette Syndrome

Tourette syndrome (TS) is a childhood neurobehavioural disorder, characterised by the presence of motor and vocal tics, typically starting in childhood but persisting in around 20% of patients into adulthood. In those patients who do not respond to pharmacological or behavioural therapy, deep brain...

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Autores principales: Akbarian-Tefaghi, Ladan, Zrinzo, Ludvic, Foltynie, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039464/
https://www.ncbi.nlm.nih.gov/pubmed/27548235
http://dx.doi.org/10.3390/brainsci6030035
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author Akbarian-Tefaghi, Ladan
Zrinzo, Ludvic
Foltynie, Thomas
author_facet Akbarian-Tefaghi, Ladan
Zrinzo, Ludvic
Foltynie, Thomas
author_sort Akbarian-Tefaghi, Ladan
collection PubMed
description Tourette syndrome (TS) is a childhood neurobehavioural disorder, characterised by the presence of motor and vocal tics, typically starting in childhood but persisting in around 20% of patients into adulthood. In those patients who do not respond to pharmacological or behavioural therapy, deep brain stimulation (DBS) may be a suitable option for potential symptom improvement. This manuscript attempts to summarise the outcomes of DBS at different targets, explore the possible mechanisms of action of DBS in TS, as well as the potential of adaptive DBS. There will also be a focus on the future challenges faced in designing optimized trials.
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spelling pubmed-50394642016-10-04 The Use of Deep Brain Stimulation in Tourette Syndrome Akbarian-Tefaghi, Ladan Zrinzo, Ludvic Foltynie, Thomas Brain Sci Review Tourette syndrome (TS) is a childhood neurobehavioural disorder, characterised by the presence of motor and vocal tics, typically starting in childhood but persisting in around 20% of patients into adulthood. In those patients who do not respond to pharmacological or behavioural therapy, deep brain stimulation (DBS) may be a suitable option for potential symptom improvement. This manuscript attempts to summarise the outcomes of DBS at different targets, explore the possible mechanisms of action of DBS in TS, as well as the potential of adaptive DBS. There will also be a focus on the future challenges faced in designing optimized trials. MDPI 2016-08-19 /pmc/articles/PMC5039464/ /pubmed/27548235 http://dx.doi.org/10.3390/brainsci6030035 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Akbarian-Tefaghi, Ladan
Zrinzo, Ludvic
Foltynie, Thomas
The Use of Deep Brain Stimulation in Tourette Syndrome
title The Use of Deep Brain Stimulation in Tourette Syndrome
title_full The Use of Deep Brain Stimulation in Tourette Syndrome
title_fullStr The Use of Deep Brain Stimulation in Tourette Syndrome
title_full_unstemmed The Use of Deep Brain Stimulation in Tourette Syndrome
title_short The Use of Deep Brain Stimulation in Tourette Syndrome
title_sort use of deep brain stimulation in tourette syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039464/
https://www.ncbi.nlm.nih.gov/pubmed/27548235
http://dx.doi.org/10.3390/brainsci6030035
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