Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety

Huntington’s disease (HD) is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS) of the pallidum is a promising symptomatic treatment targeting the core moto...

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Autores principales: Wojtecki, Lars, Groiss, Stefan Jun, Hartmann, Christian Johannes, Elben, Saskia, Omlor, Sonja, Schnitzler, Alfons, Vesper, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039467/
https://www.ncbi.nlm.nih.gov/pubmed/27589813
http://dx.doi.org/10.3390/brainsci6030038
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author Wojtecki, Lars
Groiss, Stefan Jun
Hartmann, Christian Johannes
Elben, Saskia
Omlor, Sonja
Schnitzler, Alfons
Vesper, Jan
author_facet Wojtecki, Lars
Groiss, Stefan Jun
Hartmann, Christian Johannes
Elben, Saskia
Omlor, Sonja
Schnitzler, Alfons
Vesper, Jan
author_sort Wojtecki, Lars
collection PubMed
description Huntington’s disease (HD) is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS) of the pallidum is a promising symptomatic treatment targeting the core motor symptom: chorea. This article gives an overview of preliminary evidence on pathophysiology, safety and efficacy of DBS in HD.
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spelling pubmed-50394672016-10-04 Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety Wojtecki, Lars Groiss, Stefan Jun Hartmann, Christian Johannes Elben, Saskia Omlor, Sonja Schnitzler, Alfons Vesper, Jan Brain Sci Review Huntington’s disease (HD) is one of the most disabling degenerative movement disorders, as it not only affects the motor system but also leads to cognitive disabilities and psychiatric symptoms. Deep brain stimulation (DBS) of the pallidum is a promising symptomatic treatment targeting the core motor symptom: chorea. This article gives an overview of preliminary evidence on pathophysiology, safety and efficacy of DBS in HD. MDPI 2016-08-30 /pmc/articles/PMC5039467/ /pubmed/27589813 http://dx.doi.org/10.3390/brainsci6030038 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wojtecki, Lars
Groiss, Stefan Jun
Hartmann, Christian Johannes
Elben, Saskia
Omlor, Sonja
Schnitzler, Alfons
Vesper, Jan
Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety
title Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety
title_full Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety
title_fullStr Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety
title_full_unstemmed Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety
title_short Deep Brain Stimulation in Huntington’s Disease—Preliminary Evidence on Pathophysiology, Efficacy and Safety
title_sort deep brain stimulation in huntington’s disease—preliminary evidence on pathophysiology, efficacy and safety
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039467/
https://www.ncbi.nlm.nih.gov/pubmed/27589813
http://dx.doi.org/10.3390/brainsci6030038
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