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Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study

New deep brain stimulation (DBS) electrode designs offer operation in voltage and current mode and capability to steer the electric field (EF). The aim of the study was to compare the EF distributions of four DBS leads at equivalent amplitudes (3 V and 3.4 mA). Finite element method (FEM) simulation...

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Autores principales: Alonso, Fabiola, Latorre, Malcolm A., Göransson, Nathanael, Zsigmond, Peter, Wårdell, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039468/
https://www.ncbi.nlm.nih.gov/pubmed/27618109
http://dx.doi.org/10.3390/brainsci6030039
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author Alonso, Fabiola
Latorre, Malcolm A.
Göransson, Nathanael
Zsigmond, Peter
Wårdell, Karin
author_facet Alonso, Fabiola
Latorre, Malcolm A.
Göransson, Nathanael
Zsigmond, Peter
Wårdell, Karin
author_sort Alonso, Fabiola
collection PubMed
description New deep brain stimulation (DBS) electrode designs offer operation in voltage and current mode and capability to steer the electric field (EF). The aim of the study was to compare the EF distributions of four DBS leads at equivalent amplitudes (3 V and 3.4 mA). Finite element method (FEM) simulations (n = 38) around cylindrical contacts (leads 3389, 6148) or equivalent contact configurations (leads 6180, SureStim1) were performed using homogeneous and patient-specific (heterogeneous) brain tissue models. Steering effects of 6180 and SureStim1 were compared with symmetric stimulation fields. To make relative comparisons between simulations, an EF isolevel of 0.2 V/mm was chosen based on neuron model simulations (n = 832) applied before EF visualization and comparisons. The simulations show that the EF distribution is largely influenced by the heterogeneity of the tissue, and the operating mode. Equivalent contact configurations result in similar EF distributions. In steering configurations, larger EF volumes were achieved in current mode using equivalent amplitudes. The methodology was demonstrated in a patient-specific simulation around the zona incerta and a “virtual” ventral intermediate nucleus target. In conclusion, lead design differences are enhanced when using patient-specific tissue models and current stimulation mode.
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spelling pubmed-50394682016-10-04 Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study Alonso, Fabiola Latorre, Malcolm A. Göransson, Nathanael Zsigmond, Peter Wårdell, Karin Brain Sci Article New deep brain stimulation (DBS) electrode designs offer operation in voltage and current mode and capability to steer the electric field (EF). The aim of the study was to compare the EF distributions of four DBS leads at equivalent amplitudes (3 V and 3.4 mA). Finite element method (FEM) simulations (n = 38) around cylindrical contacts (leads 3389, 6148) or equivalent contact configurations (leads 6180, SureStim1) were performed using homogeneous and patient-specific (heterogeneous) brain tissue models. Steering effects of 6180 and SureStim1 were compared with symmetric stimulation fields. To make relative comparisons between simulations, an EF isolevel of 0.2 V/mm was chosen based on neuron model simulations (n = 832) applied before EF visualization and comparisons. The simulations show that the EF distribution is largely influenced by the heterogeneity of the tissue, and the operating mode. Equivalent contact configurations result in similar EF distributions. In steering configurations, larger EF volumes were achieved in current mode using equivalent amplitudes. The methodology was demonstrated in a patient-specific simulation around the zona incerta and a “virtual” ventral intermediate nucleus target. In conclusion, lead design differences are enhanced when using patient-specific tissue models and current stimulation mode. MDPI 2016-09-07 /pmc/articles/PMC5039468/ /pubmed/27618109 http://dx.doi.org/10.3390/brainsci6030039 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alonso, Fabiola
Latorre, Malcolm A.
Göransson, Nathanael
Zsigmond, Peter
Wårdell, Karin
Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
title Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
title_full Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
title_fullStr Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
title_full_unstemmed Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
title_short Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study
title_sort investigation into deep brain stimulation lead designs: a patient-specific simulation study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039468/
https://www.ncbi.nlm.nih.gov/pubmed/27618109
http://dx.doi.org/10.3390/brainsci6030039
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