Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110

Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR...

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Autores principales: Fan, Zhen, Sun, Zhang-Hua, Liu, Zhong, Chen, Yu-Chan, Liu, Hong-Xin, Li, Hao-Hua, Zhang, Wei-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039535/
https://www.ncbi.nlm.nih.gov/pubmed/27618072
http://dx.doi.org/10.3390/md14090164
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author Fan, Zhen
Sun, Zhang-Hua
Liu, Zhong
Chen, Yu-Chan
Liu, Hong-Xin
Li, Hao-Hua
Zhang, Wei-Min
author_facet Fan, Zhen
Sun, Zhang-Hua
Liu, Zhong
Chen, Yu-Chan
Liu, Hong-Xin
Li, Hao-Hua
Zhang, Wei-Min
author_sort Fan, Zhen
collection PubMed
description Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4–6, 10–11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, and SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity against α-glucosidase with an IC(50) of 138 μM.
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spelling pubmed-50395352016-10-03 Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110 Fan, Zhen Sun, Zhang-Hua Liu, Zhong Chen, Yu-Chan Liu, Hong-Xin Li, Hao-Hua Zhang, Wei-Min Mar Drugs Article Three new diketopiperazines, dichotocejpins A–C (1–3), together with eight known analogues (4–11), were isolated from the culture of the deep-sea sediment derived fungus Dichotomomyces cejpii FS110. Their structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, and ECD calculations. Compounds 4–6, 10–11 showed significant cytotoxic activities against MCF-7, NCI-H460, HepG-2, and SF-268 tumor cell lines. Compound 1 exhibited excellent inhibitory activity against α-glucosidase with an IC(50) of 138 μM. MDPI 2016-09-09 /pmc/articles/PMC5039535/ /pubmed/27618072 http://dx.doi.org/10.3390/md14090164 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fan, Zhen
Sun, Zhang-Hua
Liu, Zhong
Chen, Yu-Chan
Liu, Hong-Xin
Li, Hao-Hua
Zhang, Wei-Min
Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_full Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_fullStr Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_full_unstemmed Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_short Dichotocejpins A–C: New Diketopiperazines from a Deep-Sea-Derived Fungus Dichotomomyces cejpii FS110
title_sort dichotocejpins a–c: new diketopiperazines from a deep-sea-derived fungus dichotomomyces cejpii fs110
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039535/
https://www.ncbi.nlm.nih.gov/pubmed/27618072
http://dx.doi.org/10.3390/md14090164
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